Chronic skin diseases and life trajectories: Development and validation of "Dermatology Long-Term Life Impact Measure"

作者：Silverberg JI, Skayem C, Flavigny AD, Le Floc'h C, Merhand S, Begolka WS, Smith ÁLT, Burstein S, Della Vedova C, Chamorey E, Kerob D, Taieb C, Ezzedine K · 发表于：Journal of the American Academy of Dermatology · 年份：2026 · DOI：10.1016/j.jaad.2025.08.042 · 研究领域：chronic skin conditions、life decisions、measure、score

BACKGROUND: To date, tools evaluating the impact of skin diseases on quality of life have investigated short-term impact, overlooking the long-term effects on important life decisions. OBJECTIVE: To create and validate the "Dermatology Long-Term Life Impact Measure (DLLIM)" questionnaire, which assesses the impact of six chronic inflammatory skin diseases on an individual's life decisions. METHODS: Following COnsensus-based Standards for the selection of health Measurement INstruments guidelines, we developed and validated DLLIM through item refinement and psychometric testing in a sample of 16,727 patients with chronic skin diseases. Factorial and construct validity were assessed, alongside internal consistency using Cronbach's alpha. Cross-cultural validation was performed in 10 languages. RESULTS: Eleven items covering education, work, and emotional life demonstrated strong unidimensionality (comparative fit index: 0.96, root mean square error of approximation: 0.071) and high internal consistency (Cronbach's α = 0.966). DLLIM scores correlated strongly with stigmatization scores (Patient Unique Stigmatization Holistic tool in dermatology), supporting construct validity. LIMITS: The majority of patients had atopic dermatitis (n = 15,223), which might limit generalizability. CONCLUSION: DLLIM is a valid, reliable instrument for measuring the long-term impact of chronic skin diseases on life decisions. It fills a gap in dermatological quality-of-life assessment and supp...