Longitudinal and cross-sectional analysis of perfluoroalkyl substances and kidney function

作者：Eklund A, Taj T, Dunder L, Lind PM, Lind L, Salihovic S · 发表于：Journal of exposure science & environmental epidemiology · 年份：2025 · DOI：10.1038/s41370-025-00785-z · 被引用次数：45 · 研究领域：Fluorocarbons、Glomerular Filtration Rate、Environmental Pollutants、Kidney、Environmental Exposure、Humans、Female、Male、Cross-Sectional Studies、Longitudinal Studies、Aged、Aged, 80 and over

BACKGROUND: Perfluoroalkyl substances (PFAS) constitute a diverse group of chemical compounds used in various consumer products. While the associations between PFAS and certain adverse human health effects are well-documented, their impact on kidney function remains less known. OBJECTIVE: The main aim of this study is to investigate the relationship between PFAS levels and kidney function (estimated glomerular filtration rate [eGFR]) utilizing a longitudinal design. METHODS: The population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study included 997 individuals at baseline (all aged 70 years, 50% females). Follow-up investigations were performed at 75 and 80 years of age. Seven major PFAS were determined in plasma using ultra-high performance liquid chromatography-mass spectrometry. Longitudinal and cross-sectional associations between PFAS and eGFR were analyzed using linear regression and mixed effects models following adjustment for sex, HDL and LDL-cholesterol, triglycerides, glucose, BMI, statin use and smoking. RESULTS: Longitudinal models demonstrated statistically significant positive associations between perfluoroundecanoic acid (PFUnDA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA)and eGFR (all P < 0.001). The associations between linear perfluorooctane sulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) followed a similar trend. In contrast, an inverse relationship between perfluoroheptanoic acid ...