The effect of nurse-led enhanced supportive care as an early primary palliative care approach for patients with advanced cancer: A randomized controlled trial

作者：Choi YY, Hong B, Rha SY, Cho S, Lee HS, Lee J · 发表于：International journal of nursing studies · 年份：2025 · DOI：10.1016/j.ijnurstu.2025.105102

BACKGROUND: Nurses play an important role in providing palliative care. However, few studies have evaluated the effectiveness of nurse-led primary palliative care. OBJECTIVE: To evaluate the effect of nurse-led enhanced supportive care as an early primary palliative care approach for advanced cancer patients. DESIGN: Randomized controlled trial. SETTING(S): This study was conducted at Yonsei Cancer Center in Seoul, Korea. PARTICIPANTS: Advanced cancer patients initiating palliative chemotherapy (N = 258) and their family caregivers (N = 120) were enrolled and completed 3-month (n = 182 patients, n = 79 caregivers) and 6-month (n = 141 patients, n = 60 caregivers) follow-up assessments. METHODS: Participants were randomly assigned to the intervention or control group (1:1). The intervention group received nurse-led enhanced supportive care, which included symptom management and coping enhancement counseling before each chemotherapy cycle (baseline to 3 months) and was delivered by trained nurses. The control group received symptom monitoring. Family caregivers only participated in the evaluation. The primary outcomes were quality of life (EORTC-QLQ C30), symptoms (ESAS), and coping (Brief COPE) at 3 months. The secondary outcomes were quality of life, symptoms, and coping at 6 months. Self-efficacy for coping with cancer (CBI-3.0 K), and depression among cancer patients and family caregivers (HADS-D) at 3 and 6 months were also evaluated. The data were analyzed using line...