Molecular Signaling Pathways of Quercetin in Alzheimer's Disease: A Promising Arena

作者：Alsaleem MA, Al-Kuraishy HM, Al-Gareeb AI, Albuhadily AK, Alrouji M, Yassen ASA, Alexiou A, Papadakis M, Batiha GE · 发表于：Cellular and molecular neurobiology · 年份：2024 · DOI：10.1007/s10571-024-01526-w · 研究领域：Alzheimer’s disease、Molecular mechanism、Neurodegenerative diseases、Neuroprotective effect、Oxidative stress、Quercetin

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment and memory deficit. Even with extensive research and studies, presently, there is no effective treatment for the management of AD. Besides, most of drugs used in the treatment of AD did not avert the AD neuropathology, and the disease still in a progressive status. For example, acetyl cholinesterase inhibitors are associated with many adverse effects, such as insomnia and nightmares. As well, acetylcholinesterase inhibitors augment cholinergic neurotransmission leading to the development of adverse effects related to high acetylcholine level, such as salivation, rhinorrhea, vomiting, loss of appetite, and seizure. Furthermore, tacrine has poor bioavailability and causes hepatotoxicity. These commonly used drugs do not manage the original causes of AD. For those reasons, natural products were repurposed for the treatment of AD and neurodegenerative diseases. It has been shown that phytochemicals produce neuroprotective effects against the development and progression of neurodegenerative diseases by different mechanisms, including antioxidant and anti-inflammatory effects. Quercetin (QCN) has been reported to exert an effective neuroprotective effect against AD and other neurodegenerative diseases by lessening oxidative stress. In this review, electronic databases such as PubMed, Scopus, and Web of Science were searched for possible relevant studies and article linking the effect of QC...