Per- and polyfluoroalkyl substances, apolipoproteins and the risk of coronary heart disease in US men and women

作者：Zhu L, Liu B, Hu Y, Wang M, Furtado JD, Rimm EB, Grandjean P, Sun Q · 发表于：Environmental health : a global access science source · 年份：2024 · DOI：10.1186/s12940-024-01147-2 · 被引用次数：64 · 研究领域：Fluorocarbons、Coronary Disease、Alkanesulfonic Acids、Apolipoproteins、Humans、Female、Middle Aged、Male、Case-Control Studies、United States、Aged、Adult

BACKGROUND: Existing evidence for associations of per- and polyfluoroalkyl substances (PFASs) with blood lipids, lipoproteins and apolipoproteins (apo), and coronary heart disease (CHD) risk is limited and inconsistent. This study aims to explore associations between plasma PFASs, blood lipoprotein subspecies defined by apolipoproteins, and CHD risk. METHODS: A case-control study of CHD was conducted in the Health Professionals Follow-Up Study (HPFS) and Nurses' Health Study (NHS). Among participants initially free of cardiovascular disease at blood collection in 1994 (HPFS) or 1990 (NHS), 101 participants who developed non-fatal myocardial infarction or fatal CHD were identified and confirmed. A healthy control was matched to each case for age, smoking status, and date of blood draw. Plasma levels of perfluorohexane sulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), total perfluorooctane sulfonic acid (PFOS), branched PFOS (brPFOS), linear PFOS (nPFOS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured. Conditional logistic regression and cubic spline regression models were used to examine associations between baseline PFASs and CHD risk. Linear regression models were applied to study PFAS associations with lipids and their subfractions. RESULTS: After multivariate adjustments, total PFOS, brPFOS and nPFOS were significantly associated with increased risk of developing CHD, and HRs (95% CIs) per log(ng/mL) increment of PFASs were 3.66 (1.36-...