Investigating the effects of Ginkgo biloba leaf extract on cognitive function in Alzheimer's disease

作者：Zhu C, Liu J, Lin J, Xu J, Yu E · 发表于：CNS neuroscience & therapeutics · 年份：2024 · DOI：10.1111/cns.14914 · 研究领域：Alzheimer's disease、Ginkgo biloba leaf extract、PI3K/AKT/NF‐κB signaling pathway、kaempferol、luteolin、quercetin

AIMS: Alzheimer's disease (AD) is a neurodegenerative disorder with limited treatment options. This study aimed to investigate the therapeutic effects of Ginkgo biloba leaf extract (GBE) on AD and explore its potential mechanisms of action. METHODS: Key chemical components of GBE, including quercetin, luteolin, and kaempferol, were identified using network pharmacology methods. Bioinformatics analysis revealed their potential roles in AD through modulation of the PI3K/AKT/NF-κB signaling pathway. RESULTS: Mouse experiments demonstrated that GBE improved cognitive function, enhanced neuronal morphology, and reduced serum inflammatory factors. Additionally, GBE modulated the expression of relevant proteins and mRNA. CONCLUSION: GBE shows promise as a potential treatment for AD. Its beneficial effects on cognitive function, neuronal morphology, and inflammation may be attributed to its modulation of the PI3K/AKT/NF-κB signaling pathway. These findings provide experimental evidence for the application of Ginkgo biloba leaf in AD treatment and highlight its potential mechanisms of action.