Associations between perfluoroalkyl substances and lipid profile in a highly exposed young adult population in the Veneto Region

作者：Canova C, Barbieri G, Zare Jeddi M, Gion M, Fabricio A, Daprà F, Russo F, Fletcher T, Pitter G · 发表于：Environment international · 年份：2020 · DOI：10.1016/j.envint.2020.106117 · 研究领域：Alkanesulfonic Acids、Environmental Pollutants、Fluorocarbons、Adult、Caprylates、Cross-Sectional Studies、Female、Humans、Italy、Lipids、Pregnancy、Young Adult

BACKGROUND: Residents of a large area of the Veneto Region (North-Eastern Italy) were exposed for decades to drinking water contaminated by perfluoroalkyl substances (PFAS). PFAS have been consistently associated with raised serum lipids, mainly in cross-sectional studies and in background exposure contexts, but the shape of the dose-response relationships has been poorly investigated. The objectives of our study were to evaluate the association between serum PFAS and serum lipids and their dose-response patterns in a large exposed population. METHODS: A cross-sectional study was conducted in 16,224 individuals aged 20-39 years recruited in the regional health surveillance program. 15,720 subjects were analysed after excluding pregnant women (n = 327), participants reporting use of cholesterol lowering medications (n = 67) or with missing information on the selected covariates (n = 110). Twelve PFAS were measured by HPLC-MS in serum; three (PFOA, PFOS and PFHxS) were quantifiable in at least 50% of samples. Non-fasting serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and triglycerides were measured by enzymatic assays in automated analysers and low-density lipoprotein cholesterol (LDL-C), non-HDL cholesterol and total/HDL cholesterol ratio were calculated. The associations between natural log (ln) transformed PFAS and lipids were assessed through generalized additive models using linear regression and smoothing thin plate splines, adjusted for poten...