Investigation of Acoustic Cardiographic Parameters before and after Hemodialysis

作者：Tsai HJ, Tsai YC, Huang JC, Wu PY, Chen SC, Chiu YW, Chang JM, Chen HC · 发表于：Disease markers · 年份：2019 · DOI：10.1155/2019/5270159 · 被引用次数：62 · 研究领域：Stroke Volume、Acoustics、Ankle Brachial Index、Brachial Artery、Case-Control Studies、Electrocardiography、Female、Follow-Up Studies、Heart Failure、Humans、Kidney Failure, Chronic、Male

Patients with end-stage renal disease are at an increased risk of cardiovascular diseases and associated mortality. Acoustic cardiography is a technique in which cardiac acoustic data is synchronized with electric information to detect and characterize heart sounds and detect heart failure early. The aim of this study was to investigate acoustic cardiographic parameters before and after hemodialysis (HD) and their correlations with ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and ratio of brachial preejection period to ejection time (bPEP/bET) obtained from an ABI-form device in HD patients. This study enrolled 162 HD patients between October 2016 and April 2018. Demographic, medical, and laboratory data were collected. Acoustic cardiography was performed before and after HD to assess parameters including third heart sound (S3), fourth heart sound (S4), systolic dysfunction index (SDI), electromechanical activation time (EMAT), and left ventricular systolic time (LVST). The mean age of the enrolled patients was 60.4 ± 10.9 years, and 86 (53.1%) patients were male. S4 (p < 0.001) and LVST (p < 0.001) significantly decreased after HD, but EMAT (p < 0.001) increased. Multivariate forward linear regression analysis showed that EMAT/LVST before HD was negatively associated with albumin (unstandardized coefficient β = -0.076; p = 0.004) and ABI (unstandardized coefficient β = -0.115; p = 0.011) and positively associated with bPEP/bET (unstandardized coeff...