Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer

作者：Halbrook CJ, Lyssiotis CA · 发表于：Cancer cell · 年份：2017 · DOI：10.1016/j.ccell.2016.12.006 · 研究领域：FDG-PET、HP-MRI、Kras、PDAC、metabolic crosstalk、metabolic imaging、metabolic reprogramming、pancreatic cancer、stroma、tumor metabolism

Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of cancer-related death. The high mortality rate results from a lack of methods for early detection and the inability to successfully treat patients once diagnosed. Pancreatic cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-autonomous pathways, the unique physiology of the tumor microenvironment, and interactions with non-cancer cells. In this review, we discuss how recent efforts delineating rewired metabolic networks in pancreatic cancer have revealed new in-roads to develop detection and treatment strategies for this dreadful disease.