Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z

作者：Shangshang Qin, Hui Qi, Qijing Zhang, Di Zhao, Zhenzhen Liu, Hao Tian, Lijuan Xu, Hui Xu, Mengmeng Zhou, Xianju Feng, Hong‐Min Liu · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2015 · DOI：10.1128/aac.00292-15 · 被引用次数：48 · 研究领域：Antibiotic Resistance in Bacteria、Infections and bacterial resistance、Pharmaceutical and Antibiotic Environmental Impacts

Acquisition of blaNDM-1 in bacterial species, such as Proteus mirabilis that is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate of P. mirabilis (PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novel Salmonella genomic island 1 variant on chromosome.