STUDIES OF ACIDOSIS

作者：Donald D. Van Slyke · 发表于：Journal of Biological Chemistry · 年份：1921 · DOI：10.1016/s0021-9258(18)86053-7 · 被引用次数：124 · 研究领域：Renal function and acid-base balance

The possible variations in the acid-base balance of the blood may be stated as follows: the blood bicarbonate may be high, low, or normal, and in each of these conditions the pH may be high, low, or normal.There are as thus classified nine theoretically possible conditions.Only one of them is normal, that in which both bicarbonate and pH are within the normal limits.At the time of the first paper of this series (Van Slyke and Cullen, 1917) only two of the abnormal possibilities had come under clinical observation, that in which bicarbonate is low, and pH normal (compensated acidosis), and that in which bicarbonate is very low, and pH also low (uncompensated acidosis).Now, however, as the result of the recent work of Y. Henderson and Haggard, of Scott, of Milroy, of Collip, of Davies, Haldane, and Kennaway, of Grant and Goldman, of Peters and Barr, and of others, it is known that the other six abnormal possibilities can be produced experimentally, and that at least some of them occur clinically.For this reason it has seemed desirable to enlarge the view presented in our former paper in order to include within it these conditions.The Normal and Abnormal Ranges of Hydrion Concentrakna of the Blood Plasma and Other Extracellular Fluids.-Theaverage normal hydrion concentration of the blood plasma lies at or near the slightly alkaline point H+ = 4 X lo-*, or pH = 7.4.This figure was estimated on the basis of material then available by L. J. Henderson in 1909, and has been confirmed...