Gut Microbiota and Metabolic Disorders

作者：Kyu Yeon Hur, Myung‐Shik Lee · 发表于：Diabetes & Metabolism Journal · 年份：2015 · DOI：10.4093/dmj.2015.39.3.198 · 被引用次数：262 · 研究领域：Gut microbiota and health、Diet and metabolism studies、Diet, Metabolism, and Disease

Gut microbiota plays critical physiological roles in the energy extraction and in the control of local or systemic immunity. Gut microbiota and its disturbance also appear to be involved in the pathogenesis of diverse diseases including metabolic disorders, gastrointestinal diseases, cancer, etc. In the metabolic point of view, gut microbiota can modulate lipid accumulation, lipopolysaccharide content and the production of short-chain fatty acids that affect food intake, inflammatory tone, or insulin signaling. Several strategies have been developed to change gut microbiota such as prebiotics, probiotics, certain antidiabetic drugs or fecal microbiota transplantation, which have diverse effects on body metabolism and on the development of metabolic disorders.