Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody.

作者：Georg Kraal, Marga Janse · 发表于：PubMed · 年份：1986 · 被引用次数：224 · 研究领域：Immunotherapy and Immune Responses、Galectins and Cancer Biology、Monoclonal and Polyclonal Antibodies Research

A monoclonal antibody, MOMA-1, is described that recognizes the marginal metallophilic macrophages in the mouse spleen. The cells are localized at the marginal sinus forming a ring around the periarteriolar lymphocyte sheath and follicular areas at the inner side of the marginal zone. They show high non-specific esterase activity and can be distinguished from the marginal zone macrophages by antibody staining and the lack of FITC-Ficoll uptake. The relationship of MOMA-1-positive cells with other macrophage populations is discussed.