Acute Cortisol Administration Triggers Craving in Individuals with Cocaine Dependence

作者：Igor Elman, Scott E. Lukas, Scott E. Lukas, PhD, Katherine H. Karlsgodt, Rachel Maddux, Gregory P. Gasic, PhD, and Hans C. Breiter, Maurizio Fava · 发表于：Psychopharmacology Bulletin · 年份：2025 · DOI：10.64719/pb.4174 · 被引用次数：39 · 研究领域：Stress Responses and Cortisol、Heart Rate Variability and Autonomic Control、Substance Abuse Treatment and Outcomes

Stress is often mentioned as a factor in the development of drug abuse. Twelve cocaine dependent individuals were administered a stress hormone, cortisol, along with cocaine and saline via intravenous boluses, in a double-blind, counterbalanced fashion. Self-reports of mood states were collected prior to, during, and 20 minutes after each bolus was administered. Cortisol produced significant increases in craving while cocaine significantly elevated all subjective ratings (ie, craving, high, rush, and low). These pilot data suggest that cortisol can induce a state that is associated with drug abuse.