Patterns of Radiation Therapy During the COVID-19 Pandemic: Results from the Multicenter, Cross-Sectoral Registry of the German National Pandemic Cohort Network (NAPKON)

作者：Charlotte Flasshove, Jörg Andreas Müller, Ramsia Geisler, Janne Vehreschild, Shimita Raquib, Katharina Appel, Steffi Ulrike Pigorsch, Sina M. Pütz, Christian Rafael Torres Reyes, Christoph Römmele · 发表于：Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver · 年份：2026 · 研究领域：COVID-19 and healthcare impacts、Advances in Oncology and Radiotherapy、Effects of Radiation Exposure

Background: Cancer patients receiving or having received radiotherapy (RT) represent a clinically vulnerable group during the COVID-19 pandemic. However, systematic data on their clinical course, comorbidities, and vaccination status are limited. The German National Pandemic Cohort Network (NAPKON), established to systematically collect comprehensive clinical data on COVID-19 patients nationwide, provides a unique opportunity to address this gap. This study aimed to describe radiation therapy patterns and COVID-19-related clinical characteristics among patients documented within the NAPKON Cross-Sectoral Platform (SUEP). Methods: This multicenter, descriptive analysis was conducted within the framework of the German National Pandemic Cohort Network (NAPKON). All patients with documented RT and confirmed SARS-CoV-2 infection were identified in the SUEP database. RT was classified relative to the documented infection date as occurring before, during, or after infection. Demographic, clinical, laboratory, imaging, and vaccination data were extracted and analyzed descriptively. Due to the small sample size, no correlation or multivariable analyses were performed. Results: A total of n = 90 patients were included in the analysis. The median age was 65 years (range 22–90), and 56% were male. Most patients (93%) received one course of RT, most frequently targeting specific organ systems (54%), while total body irradiation was performed in 4%. The median radiation dose was 45 Gy (IQR...