Bismuth-infused manganese molybdate nanostructures: a robust electrochemical platform for ultrasensitive uric acid detection

作者：Chandraju Siddegowda Chidan Kumar, K. S. Mahesh Lohith, Mudaganduru Nagaraja Ramachandra, Mezna Saleh Altowyan, Payyanur Sumesh, Yarehalli Honnappa Pavithra, Siddegowda Chandraju · 发表于：Journal of Electrochemical Science and Engineering · 年份：2026 · DOI：10.5599/jese.3475 · 研究领域：Electrochemical sensors and biosensors、Gout, Hyperuricemia, Uric Acid、Conducting polymers and applications

Sensitive and real-time monitoring of uric acid (UA) is essential for the effective management of metabolic disorders such as hyperuricemia and Lesch-Nyhan syndrome. Herein, MnMoO4 (MMO) and bismuth-doped MnMoO4 (BMMO) nanoparticles (NPs) were synthesized via a combustion method and employed to fabricate MMO-ME and BMMO-ME electrochemical sensors. Bi3+ incorporation was associated with lattice distortion and improved electro­chemical charge-transfer characteristics, as evidenced by the electrochemical measurements. Electrochemical studies revealed a diffusion-controlled, proton-coupled UA oxidation process with optimal response at physiological pH (7.0), while NP loading optimization identified 4 mg as the ideal composition. Compared to MMO-ME, the BMMO-ME electrode exhibited higher anodic current and lower peak-to-peak separation, and faster electron-transfer kinetics due to the synergistic bimetallic effect. Differential pulse voltam­metry enabled ultrasensitive UA detection over a wide linear range (10 to 60 nM) with low detection limits of 5.0 (MMO-ME) and 4.5 nM (BMMO-ME). Both sensors demonstrated excellent stability, repeatability and reproducibility (RSD < 2 %), while BMMO-ME showed superior resistance to surface fouling. Accurate UA recovery (98 to 103 %) from tap water confirmed practical applicability. Overall, this work highlights Bi-induced defect engineering as an effective strategy to activate MMO and establishes BMMO-ME as a robust, sensitive, and reliable pla...