Belzutifan plus lenvatinib versus cabozantinib in patients with previously treated advanced renal cell carcinoma (LITESPARK-011): an open-label, randomised, controlled, phase 3 trial

作者：Robert John Motzer, Robert John Motzer, Ray McDermott, Se Hoon Park, Mauricio Burotto, Roberto Iacovelli, Elena Verzoni, Cristina Suárez, Masatoshi Eto, Hernan Javier Cutuli, Camillo Porta, Ray Manneh Kopp, Sylvie Rottey, Guillermo de Velasco, Begona Perez Valderrama, Arun Azad, Ugo De Giorgi, Michel Pavic, Piotr Tomczak, Robert Figlin, Hans M. Westgeest, Annalisa Guida, Andrea Necchi, Fabio A Schutz, Britt B M Suelmann, John B A G Haanen, Sammy Shuai Yuan, Rodolfo F. Perini, Daniel Y C Heng, Daniel Y C Heng, Manuela Schmidinger, Juan Pablo Sade, Ernesto Pablo Korbenfeld, Marcelo Daniel Tatangelo, Juan Ignacio Hernández Morán, Hernan Javier Cutuli, Alejandro Dri, Babak Tamjid, Christopher Hocking, Arun Azad, Laurence Krieger, Ferdinand Luger, Clemens Mayr, Manuela Schmidinger, Dora Niedersuess‐Beke, Johannes Meran, Martin Pichler, Thomas Bauernhofer, Sylvie Rottey, Benoit Beuselinck, Christine Gennigens, Nieves Martinez Chanza, Spyridon Sideris, Marco Gizzi, Jean-Pascal Machiels, Alan A. Azambuja, Silvana Vale, Fabio A.B. Schutz, Silvio Correia Sales, Mahmoud Abdelsalam, Michel Pavic, Catherine Sperlich, Francisco Vera-Badillo, Daniel Heng, Christian Kollmannsberger, Naveen S. Basappa, Georg Arnold Bjarnason, Aly-Khan Lalani, Nicolas Marcoux, Dominick Bosse, Mauricio Burotto, Eduardo Yanez Ruiz, Ricardo Brugés, Martha Liliana Alarcón, Javier Cuello Lopez, Ray Manneh Kopp, Tomáš Büchler, Jindřich Kopecký, Alexandr Poprach, Pavel Tolinger, Tomáš Büchler, Katriina Jalkanen, Kaisa Leea Sunela, Krista Kankaanranta, Kalle Ensio Mattila, Vesa Valiaho, Sophie Abadie‐Lacourtoisie, Frédéric Rolland, Marine Gross-Goupil, Sabrina Falkowski, Ahmed Khalil, Christine Chevreau, Damien Pouessel, Loı̈c Mourey, Jean-Christophe Eymard, Delphine Borchiellini, Philippe Barthelemy, Marinela Augustin, Andreas Becker, Séverine Banek, Clara Humke, Markus Grabbert, Stefan Siemer, Julia Heinzelbecker, Peter Reichardt, Juliane Kuenzel, Florian Seseke, Thomas Steiner, Volker Perst, Matthias Saar, Jennifer Kranz, Sofia Shah, Ramona Stelmach, Stefanie Zschaebitz, Maria De Santis, Sofia Baka, Aristotelis Bamias, Angelos Koutras, Marinos Tsiatas, Flora Zagouri, Ray McDermott, John McCaffrey, Giuseppe Procopio, Elena Verzoni, Sergio Bracarda, Annalisa Guida, Camillo Porta, Elisa Biscaldi, Andrea Premoli, Sabrina Del Buono, Alketa Hamzaj, Consuelo Buttigliero, Armando Santoro, Ugo Federico Francesco De Giorgi, Cristian Lolli, Andrea Necchi, Andrea Necchi, Roberto Iacovelli, Nobuaki Matsubara, Yuji Miura, Koichi Suyama, Satoshi Anai, Makito Miyake, Makoto Sumitomo, Hideaki Miyake, Yuto Matsushita, Masatoshi Eto, Go Kimura, Noboru Nakaigawa, Hisashi Hasumi, Naoya Masumori, Yasuhisa Fujii, Kazutoshi Fujita, Ryuichi Mizuno, Mototsugu Oya, Taigo Kato, Yoshihiko Tomita, Kazutoshi Yamana, Naoto Kamiya, Tsunenori Kondo, Yasutomo Nakai, Akira Nagahara, Mutsushi Kawakita, Toshinari Yamasaki, John B.A.G. Haanen, Franchette van den Berkmortel, Marco Ben Polee, Paul Hamberg, Britt B.M. Suelmann, H.M. Westgeest, Astrid van der Veldt, Danny Houtsma, Paweł Wiechno, Piotr Tomczak, Bogdan Żurawski, Marek Ziobro, Tudor Eliade Ciuleanu, Cristina Ligia Cebotaru, Michael Schenker, Igor Utyashev, Nikolay Keshishev, Aleksander Bystrov, Dmitry Vladislavovich Perlin, Andrey Vladimirovich Semenov, Anastasia Mochalova, Nikolay Viktorovich Kislov, Jae Lyun Lee, Se Hoon Park, Woo Kyun Bae, Oscar Reig Torras, J.P. Maroto Rey, Aurea Molina Díaz, Begona Pérez Valderrama, Javier Puente Vazquez, Jóse Ángel Arranz Arija, Cristina Suárez Rodriguez, Guillermo de Velasco Oria de Rueda, Richard Cathomas, Anja Lorch, Petros Tsantoulis, Ursula Vogl, Paul Nathan, Anand Sharma, Matthew Sephton, Gordon Urquhart, Poulam Patel, Naveed Sarwar, Mark Beresford, Sing Yu Moorcraft, Awais Jalil, Steven Ades, Carlos Alemany, Claud Grigg, Daniel Marcus Anderson, Michael Benjamin Atkins, Gary R. MacVicar, Thomas Paul Bradley, Thomas Paul Bradley, Waddah Arafat, Sreenivasa Chandana, Robert Figlin, Arash Rezazadeh Kalebasty, Julio Hajdenberg, Daniel Landau, Hatem Hassanein, John Clark Henegan, Alan Tan, Thomas Christopher Westbrook, Mark D. Kochenderfer, Sandy Liu, Alexandra Drakaki, Robert Motzer, Robert Motzer, Suresh G. Nair, Petros Nikolinakos, Lindsay C. Overton, Joseph Maly, Mikhail Shtivelband, Eric A. Singer, Biren Saraiya, Przemyslaw Twardowski, Haris Zahoor, Zhentao Zhang, Brendan Connell, Scott Tykodi, Timothy Byun, Michael Roger Harrison, Pedro Barata, Brian Lewis, Benjamin Maughan · 发表于：The Lancet · 年份：2026 · DOI：10.1016/s0140-6736(26)01089-5 · 被引用次数：3 · 研究领域：Renal cell carcinoma treatment、Chemotherapy-induced organ toxicity mitigation、Renal and related cancers