Course of Portal Hypertension and Its Prognostic Impact After Liver Transplantation

作者：Nina Dominik, Petra Dinjar‐Kujundzic, Sandra Lovrekovic, Hrvoje Premec, Felix Kristandl, Lorenz Balcar, Maja Mijić, Miloš Lalovac, Benedikt Hofer, Lukas Hartl, Christian Sebesta, Georg Kramer, Paul Thöne, Mattias Mandorfer, M Trauner, Danko Mikulić, Stipislav Jadrijević, Georg Gyöeri, Gabriela Berlakovich, Tajana Filipec Kanižaj, Thomas Reiberger · 发表于：United European Gastroenterology Journal · 年份：2026 · DOI：10.1002/ueg2.70268 · 研究领域：Liver Disease and Transplantation、Organ Transplantation Techniques and Outcomes、Liver Diseases and Immunity

BACKGROUND: While portal hypertension (PH) typically resolves after liver transplantation (LT), persistence of PH may affect post-transplant outcomes. We assessed the evolution of PH after LT and its impact on adverse outcomes. METHODS: We recorded clinical, laboratory, and imaging parameters of LT recipients between 2016 and 2022 in Vienna and Zagreb. Persistent features of CSPH were defined as the presence of portosystemic collaterals, platelet count (PLT) ≤ 110 G/L, and/or splenomegaly (≥ 13 cm). PH-related clinical events were defined as variceal bleeding, ascites requiring intervention, hepatic hydrothorax, portal vein thrombosis, or liver-related death within 12 months post-LT. Post-LT outcomes were analyzed using landmark Cox regression for 3 months post-LT. RESULTS: Of 645 LT recipients (76% male, median age 59 years) listed with a median MELD of 15 points and PLT of 99 G/L, features of CSPH were present in 537 (83.3%) at baseline. At year 1 after LT, MELD improved to 9 (IQR 7-12), PLT increased to 160 G/L (IQR 120-207), and features of CSPH persisted in 251/453 classifiable patients (55.4%). PH events occurred in 75 (11.6%) and 84 (13%) deaths. In a landmark analysis from 3 months post-LT (n = 521, 29 deaths), persistent thrombocytopenia (< 110 G/L) at M3 independently predicted mortality (aHR 2.31, 95% CI 1.01-5.30, p = 0.048) after adjustment for MELD, age, CRP, and pre-LT TIPS. CONCLUSIONS: While PH improves after LT, features of CSPH persisted in 55% of classifia...