The TCN1 Paradox: Unraveling the Dual Role of Transcobalamin I in Colorectal Cancer—From Metabolic Regulation to Oncogenic Signaling

作者：Xinqiang Zhu, Beibei Ge, Siwei Shan, Linchun Wen · 发表于：Dove Medical Press (Taylor and Francis Group) · 年份：2026 · 研究领域：Folate and B Vitamins Research、Porphyrin Metabolism and Disorders、Alcoholism and Thiamine Deficiency

Xinqiang Zhu,1,* Beibei Ge,2,* Siwei Shan,3 Linchun Wen41Department of General Surgery, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu, 223800, People’s Republic of China; 2Department of Dentistry, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu, 223800, People’s Republic of China; 3Department of Ultrasound, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu, 223800, People’s Republic of China; 4Department of Oncology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu, 223800, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinqiang Zhu, Department of General Surgery, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu, 223800, People’s Republic of China, Tel +86-18012186778, Email zhuxinqiang2009@126.comBackground: Colorectal cancer (CRC) remains a leading cause of cancer mortality. While genetic drivers are well-characterized, epigenetic alterations—particularly DNA methylation—are increasingly recognized as critical contributors. The vitamin B12 transporter Transcobalamin I (TCN1) has recently emerged as an epigenetically regulated gene with context-dependent oncogenic functions.Main Body: This review synthesized current evidence positioning TCN1 at the intersection of metabolic regulation and oncogenic signaling. We critically evaluated TCN1’s consistent ove...