Cellular hitchhiking of selenium carbon dots for targeted macrophage polarization in acute lung injury

作者：Jing Wang, Rongrong Xu, Hongchen Dai, Yuanguang Li, Huaqing Liu, Xianglei Liu, Ling Fu, Yubao Zhou, Shaohu Huo, Shenggang Ding · 发表于：Journal of Materials Chemistry B · 年份：2026 · DOI：10.1039/d6tb01183g · 研究领域：Carbon and Quantum Dots Applications、Selenium in Biological Systems、Sulfur Compounds in Biology

evaluations using an LPS-induced ALI mouse model demonstrated that intravenously administered SC@OMVs preferentially accumulate in inflamed lung tissues. Moreover, SC@OMVs effectively suppressed cytokine storms and promoted the repair of the alveolar-capillary barrier by modulating the TLR4/MyD88/NF-κB signaling pathway. By synergistically integrating the targeted biological delivery capabilities of OMVs with the potent intracellular immunomodulatory and antioxidant properties of selenium, the use of SC@OMVs represents a highly promising, precise therapeutic strategy for the comprehensive management of ALI.