Analysis of the safety and efficacy of single-stage spinal cord stimulation implantation under general anesthesia for high-risk diabetic feet

作者：Xiaochen Chen, Baochang Zhu, Zhitao Li · 发表于：IBRO Neuroscience Reports · 年份：2026 · DOI：10.1016/j.ibneur.2026.07.020 · 研究领域：Pain Management and Treatment、Vagus Nerve Stimulation Research、Pain Mechanisms and Treatments

Objective To evaluate the safety and efficacy of implantation of a one-stage spinal cord stimulation (SCS) system under general anesthesia in patients with high-risk diabetic feet. Methods A retrospective analysis was performed on 25 patients who were diagnosed with high-risk diabetic feet and who underwent implantation of an SCS system between January 2023 and May 2024. The procedure was conducted under general anesthesia with intraoperative electrophysiological monitoring. All patients were followed up for one year postoperatively. The outcomes, including pain intensity, foot skin temperature, dorsalis pedis artery flow velocity, and F-wave occurrence rate on electromyography, were assessed at baseline and at multiple time points after surgery. Additionally, postoperative complications such as infection, electrode displacement, and lead fracture, as well as rates of new ulcer formation, amputation, and mortality, were recorded. Results All patients completed the 12-month follow-up period. The efficacy rate was 100% at 7 days postoperatively and 88% at 6 months, and the incidence of new ulcers at 1 year was 8%. Significant improvements in pain, foot skin temperature, and arterial flow velocity were observed within 7 days after implantation ( P =0.000), with sustained therapeutic effects lasting beyond 6 months ( P '=0.000). However, no further improvement in the dorsalis pedis artery flow velocity was noted with prolonged stimulation duration ( P "=0.459). Electromyography r...