Association between fasting serum uric acid levels and Alzheimer's disease in nursing home residents: a cross-sectional study

作者：Xia Li, Wenjian Zhao, Jinchi Zhou, Jiaqi Qiu · 发表于：Frontiers in Nutrition · 年份：2026 · DOI：10.3389/fnut.2026.1878852 · 研究领域：Gout, Hyperuricemia, Uric Acid、Rheumatoid Arthritis Research and Therapies、Tryptophan and brain disorders

Introduction Evidence regarding the association between fasting serum uric acid (FSUA) and Alzheimer's disease (AD) is limited and inconsistent. This study investigated the association between FSUA levels and AD. Methods In this cross-sectional study, 852 participants from a hospital specializing in geriatric care were enrolled. Multivariable logistic regression analysis, restricted cubic spline curves, and subgroup analyses were employed to analyze the association between FSUA and AD. Results The average age of eligible participants was 81.0 ± 8.8 years; 23% were patients with AD and 33.7% were male. Multivariate logistic regression analysis revealed an inverse relationship between FSUA levels and AD. Specifically, a 10 μmol/L increase in FSUA was associated with a 5% decrease in AD odds (OR, 0.95; 95% confidence interval [CI], 0.93–0.97). When FSUA levels were divided into quartiles, the higher quartiles showed progressively lower odds of developing AD than those in the lowest quartiles ( p for trend < 0.001). No interactions were observed between FSUA and AD. Restricted cubic spline regression model demonstrated a linear inverse association between the odds of AD and FSUA levels. Conclusion We observed a negative association between FSUA levels and AD. Further prospective studies are required to confirm this causal relationship.