Associations Between Cerebral Amyloid Angiopathy, Cognitive Impairment, and Depressive Symptoms

作者：Nikita Nukala, Ryan T. Muir, Andrew E. Beaudin, Cheryl R. McCreary, Myrlene Gee, Krista Nelles, Feryal Saad, Janina Valencia, Glen C. Jickling, Dylan X. Guan, Zahinoor Ismail, Richard Camicioli, Eric E. Smith · 发表于：Neurology · 年份：2026 · DOI：10.1212/wnl.0000000000218354 · 研究领域：Intracerebral and Subarachnoid Hemorrhage Research、Dementia and Cognitive Impairment Research、Neurological Disease Mechanisms and Treatments

BACKGROUND AND OBJECTIVES: Cerebral amyloid angiopathy (CAA) is associated with intracerebral hemorrhage, cognitive decline, and dementia. We examined (1) associations between CAA, cognitive impairment, and depressive symptoms; (2) whether depressive symptoms mediate the relationship between CAA and cognition; and (3) whether CAA neuroimaging markers predict depressive symptom severity. METHODS: Recruitment occurred through memory and stroke prevention clinics across 2 sites. Cross-sectional data from probable CAA and controls were analyzed. Neuropsychological tests were grouped into episodic memory, executive function, and processing speed domains. Scores ≥5 on the Geriatric Depression Scale: Short Form (GDS-15) defined "possible depression." Regression and mediation analyses examined associations among CAA status, cognition, and depressive symptoms, and in CAA, associations between neuroimaging biomarkers and GDS-15. RESULTS: = 0.047). DISCUSSION: CAA participants exhibited greater depressive symptoms and poorer cognition than controls. Depressive symptoms mediated a small portion of the association between CAA and cognition. Cerebral cortex damage may underlie some depressive symptoms. Interventions targeting CAA-related neurodegeneration and treatment of depressive symptoms may support cognitive health in CAA.