Lactobionic acid-modified zein/sodium alginate nanoparticles for oral delivery of Ganoderma lucidum triterpenoids in alcoholic liver disease

作者：Yanjun Chen, Wenjia Li, Jiayue Song, Xinyu Hou, Xiaobing Song, Qianli Ma, Quanliang Li, Ping Chen · 发表于：npj Science of Food · 年份：2026 · DOI：10.1038/s41538-026-01033-w · 研究领域：Fungal Biology and Applications、Polysaccharides and Plant Cell Walls、Silymarin and Mushroom Poisoning

Alcoholic liver disease (ALD) is a major global public health concern. Although Ganoderma lucidum triterpenoid-enriched extract (GLE) possesses notable hepatoprotective potential, its inherent hydrophobicity and poor oral bioavailability have limited its clinical application. In this study, a lactobionic acid-modified zein/sodium alginate nanoplatform (LA-GL/ZSNPs) was engineered for enhanced liver delivery of GLE. The LA-GL/ZSNPs were successfully fabricated through hydrophobic core loading, hydrogen bond-mediated stabilization, and surface modification with lactobionic acid, yielding uniform spherical nanoparticles with excellent physicochemical stability, pH-responsive release behavior, and sustained-release properties. LA-GL/ZSNPs exhibited enhanced liver accumulation in vivo, showing a 71.07% higher hepatic accumulation than free GLE70 within 24 h. In a mouse model of ALD, oral administration of LA-GL/ZSNPs significantly alleviated hepatocellular injury, oxidative stress, and inflammation, while restoring lipid metabolism. Moreover, this modulated gut microbiota composition, increasing the relative abundances of Lactobacillus , Prevotella , and Akkermansia . This study introduces an oral nanoplatform that integrates enhanced hepatic accumulation with controlled-release functionality for the treatment of ALD.