FNIP1 variants are associated with favourable metabolism in 1 million humans

作者：George Hindy, Rene C. Adam, Olukayode Sosina, Dwaine Pryce, David Blair, Joseph Herman, Joseph Lee, Peter Dornbos, Ernst Mayerhofer, Arthur Gilly, Charleen Hunt, Benjamin Geraghty, Karl Landheer, Liron Ganel, Antoine Baldassari, Chuanyi Zhang, Ivory Mintah, Daphne Sun, Angel Coppola, Kyle Brown, Tram Nguyen, Xin Xia, Andrew Deubler, Adolfo Ferrando, Giovanni Coppola, Alan Shuldiner, Katherine Siminovitch, Jason Portnoy, Lyndon Mitnaul, Alison Fenney, Manuel Allen Revez Ferreira, Maya Ghoussaini, Mona Nafde, William Salerno, Lourdes Crane, Christina Beechert, Erin Fuller, Laura M. Cremona, Eugene Kalyuskin, Hang Du, Caitlin Forsythe, Zhenhua Gu, Kristy Guevara, Michael Lattari, Alexander Lopez, Kia Manoochehri, Prathyusha Challa, Manasi Pradhan, Raymond Reynoso, Ricardo Schiavo, Maria Sotiropoulos Padilla, Chenggu Wang, Sarah E. Wolf, Manan Goyal, George Mitra, Sanjay Sreeram, Rouel Lanche, Vrushali Mahajan, Sai Lakshmi Vasireddy, Gisu Eom, Krishna Pawan Punuru, Sujit Gokhale, Benjamin Sultan, Pooja Mule, Mudasar Sarwar, Muhammad Aqeel, Xiaodong Bai, Lance Zhang, Sean O’Keeffe, Razvan Panea, Evan Edelstein, Ayesha Rasool, Evan K. Maxwell, Boris Boutkov, Alexander Gorovits, Ju Guan, Lukas Habegger, Alicia Hawes, Olga Krasheninina, Samantha Zarate, Adam J. Mansfield, Joshua Backman, Kathy Burch, Adrián Campos, Sheila Gaynor, Arkopravo Ghosh, Salvador Romero Martinez, Christopher Gillies, Lauren Gurski, E. Jorgenson, Tyler Joseph, Michael Kessler, Jack Kosmicki, Priyanka Nakka, Olivier Delaneau, Anthony Marcketta, Joelle Mbatchou, Arden Moscati, Anita Pandit, Jonathan Ross, Carlo Sidore, Eli Stahl, Timothy Thornton, Sailaja Vedantam, Rujin Wang, Kuan-Han Wu, Bin Ye, Blair Zhang, Andrey Ziyatdinov, Yuxin Zou, Jingning Zhang, Kyoko Watanabe, Mira Tang, Frank Wendt, Suying Bao, Kathie Sun, Sean Yu, Aaron Zhang, David Corrigan, Dhruv Shidhaye, Chen Wang, Keyrun Adhikari, Alexander Lachmann, Mark Weiner, Brian Hobbs, Jon Silver, William Palmer, Rita Guerreiro, Amit Joshi, Sarah Graham, Erola Pairó Castiñeira, Tanima De, Luanluan Sun, Mary Haas, Juan Rodriguez-Flores, Moeen Riaz, Manav Kapoor, Gannie Tzoneva, Momodou Jallow, Anna Alkelai, Ariane Ayer, Veera Rajagopal, Sahar Gelfman, Vijay Kumar, Jacqueline Otto, Jose Bras, Silvia Álvarez, Jessie Brown, Hossein Khiabanian, Joana Revez, Kimberly Skead, Valentina Zavala, Jae Soon Sul, Lei Chen, Sam Choi, Amy Damask, Nan Lin, Charles Paulding, Sameer Malhotra, Nadia Rana, Jennifer Rico-Varela, Jaimee Hernandez, Larizbeth Romero, Ashley Paynter, Randi Schwartz, Jody Hankins, Anna Han, Samuel Hart, Ryan Smith, Ann Perez-Beals, Gina Solari, Johannie Rivera-Picart, Michelle Pagan, Sunilbe Siceron, Adam Buchanan, David J. Carey, C. L. Martin, Michelle Meyer, Kyle Retterer, David Rolston, Penn Medicine Biobank, Marylyn D. Ritchie, JoEllen Weaver, Nawar Naseer, Giorgio Sirugo, Afiya Poindexter, Yi-An Ko, Kyle P. Nerz, Jenna Dever, Aidan Harvey, Sydney Linn, Meghan Livingstone, Fred Vadivieso, Stephanie DerOhannessian, Teo Tran, Julia Stephanowski, Salma Santos, Ned Haubein, Joseph Dunn, Anurag Verma, Colleen Morse Kripke, Marjorie Risman, Renae Judy, Colin Wollack, Shefali S. Verma, Scott Damrauer, Yuki Bradford, Scott Dudek, Theodore Drivas, Heather Anderson, Christina L. Aquilante, Kelsey Arbogast, Ian M. Brooks, Elizabeth E. Burke, Emily M. Casteel, Joanne B. Cole, Curtis R. Coughlin, Jacob Crawford, Kristy Crooks, Erin Culver, Matthew J. Fisher, Teresa C. Frye, Hunter George, Chris Gignoux, Elizabeth K. Gilliland, Casey S. Greene, Emily Hearst, Audrey E. Hendricks, Randi K. Johnson, Shelby Jones, Dave Kao, Gabrielle A. Knortz, Danielle Koffenberger, Santhanagopalan Krishnamoorthy, Lisa Ku, Elizabeth Kudron, Rashawnda Lacy, Ethan M. Lange, Joe A. Lesny, Meng Lin, James Martin, Adrian M. Stewart, Alaa Radwan, Anna Tanaka, Carolina Sanchez-Wild, C. Swartz, Elise L. Shalowitz, Emily B. Todd, Hoda Sherif, J C Pattee, Jonathan Shortt, Katy E. Trinkley, Laura K. Wiley, Neda Rasouli, Nick Rafaels, Nicole L. McDaniel, Nikita Pozdeyev, Sridharan Raghavan, Vendant Vohra, James R. Cerhan, Fergus J. Couch, Janet E. Olson, Nicholas B. Larson, Zachary S. Fredericksen, Mine Cicek, Joanna M. Biernacka, Victor M. Karpyak, Prashanthi Vemuri, Vijay K. Ramanan, Mark A. Frye, Sarah A. McLaughlin, Kathryn J. Ruddy, Suzette J. Bielinski, John C. Lieske, W. Michael Hooten, Lisa A. Boardman, Richard B. Kennedy, Andrew D. Badley, Sean C. Dowdy, Jamie N. Bakkum-Gamez, Gretchen E. Glaser, Ping Yang, C. M. Vachon, Angela Dispenzieri, Samuel O. Antwi, Ann L. Oberg, Kari G. Rabe, Scott H. Kaufmann, Ellen L. Goode, William A. Cliby, J. Eric Ahlskog, James H. Bower, Peter Harris, Naveen L. Pereira, Daniel J. Ma, Robert W. Mutter, Jeanette E. Eckel‐Passow, Lisa K. Colborn, Andrew J. Danielsen, Jonathan J. Harrington, Jennifer M. Kushwaha, Mexico City Prospective Study, Malmö Diet and Cancer Study, Naga Chalasani, Tae‐Hwi L.Schwantes‐An, Andrew J. Saykin, Alex Bui, Antonia Petruse, Arash Naeim, Chris Denny, Clara Lajonchere, Clara Magyar, Dan Geschwind, Maryam Ariannejad, Paul Boutros, Paul Spellman, Sarah Dry, Stan Nelson, Albert Duntugan, Bogdan Paşaniuc, Paul Tung, Tim Chang, Yael Berkovich, Ankur Jain, Danielle Martinez, Ghouse Mohammed, Lora Illiev, Michael Broudy, Roni Haas, Shaiful Alam, Taka Yamaguchi, Yash Patel, Mount Sinai Million Health Discoveries Program, Alexander W. Charney, UTSW-Dallas Biobank, Julia Kozlitina, Jonathan Cohen, South Asia Biobank Study, Marie Loh, Prasad Katulanda, Vinitaa Jha, Anuradhani Kasturiratne, Khadija Irfan Khawaja, Malay Kanti Mridha, Ranjit Mohan Anjana, John C. Chambers, Daniel J. Rader, Olle Melander, Christopher D. Still, Jaime Berúmen, Pablo Kuri‐Morales, Jesús Alegre-Díaz, Jason Torres, Jonathan Emberson, Rory Collins, Roberto Tapia‐Conyer, Suganthi Balasubramanian, Marcus B. Jones, Michelle G. LeBlanc, Andrew Murphy, Christos A. Kyratsous, John D. Overton, Jeffrey G. Reid, Gonçalo R. Abecasis, Jonathan Marchini, Cristen J. Willer, George D. Yancopoulos, Mark W. Sleeman, Jonas Bovijn, Adam E. Locke, Aris Baras, Niek Verweij, Viktoria Gusarova, Luca A. Lotta · 发表于：Nature · 年份：2026 · DOI：10.1038/s41586-026-10864-2 · 被引用次数：1 · 研究领域：Mitochondrial Function and Pathology、Glycogen Storage Diseases and Myoclonus、Ubiquitin and proteasome pathways