Effect of ambient relative humidity and particulate matter on the levels of asthma therapy

作者：Firdian Makrufardi, Hsiao-Chi Chuang, Yuan-Chien Lin, Desy Rusmawatiningtyas, Nurnaningsih, Shu‐Min Lin, Po-Jui Chang, Chun‐Yu Lo, Chiung-Hung Lin, Chiung-Hsin Chang, Tzu-Hsuan Chiu, Pi‐Hung Tung, Kian Fan Chung, Ting‐Yu Lin · 发表于：World Allergy Organization Journal · 年份：2026 · DOI：10.1016/j.waojou.2026.101444 · 研究领域：Inhalation and Respiratory Drug Delivery、Asthma and respiratory diseases、Chemical and Physical Studies

Objective We aimed to investigate the associations of the daily mean and short-term variation in ambient relative humidity (RH), temperature, and fine particulate matter (PM 2.5 ) with asthma treatment steps. Methods We consecutively recruited 288 newly diagnosed adult patients with asthma and followed them for at least 6 months according to the Global Initiative for Asthma (GINA) strategy. Odds ratios (ORs) for higher GINA treatment steps required to achieve asthma control were estimated using logistic regression. We also conducted exposure-response analyses to explore potentially nonlinear relationships between environmental exposure and asthma treatment step across seasons. Results A 1% increase in the 1-day RH difference and a 1-μg/m3 increase in the 7-day PM2.5 difference were associated with 1.054-fold and 1.052-fold higher odds of step 4 treatment, respectively. A 1% increase in the 1-day RH difference and a 1-μg/m3 increase in the 7-day PM 2.5 difference were associated with 1.047-fold and 1.056-fold higher odds of medium-dose inhaled corticosteroids plus long-acting beta-agonists (ICS + LABA), respectively. A 1% increase in the 7-day RH mean and a 1-μg/m3 increase in the 30-day PM 2.5 difference were associated with 1.075-fold and 1.205-fold higher odds of triple inhaler therapy and biologics use, respectively. Exposure-response analyses suggested noticeable seasonal patterns for temperature and RH in relation to asthma treatment strategy. Conclusions Our exploratory...