Association of Enlarged Perivascular Spaces and Total Small Vessel Disease Burden With Kidney Function

作者：Philip S. Nash, Gareth Ambler, Jonathan G. Best, Duncan Wilson, Houwei Du, Rustam Al‐Shahi Salman, Hans Rolf Jäger, Gregory Y.H. Lip, Martina Goeldlin, Morin Beyeler, Philipp Buecke, Marwan El‐Koussy, Heinrich P. Mattle, Leonidas D Panos, Dianne H.K. van Dam-Nolen, Florian Dubost, Jeroen Hendrikse, M. Eline Kooi, Werner H. Mess, Paul J. Nederkoorn, Nicolas Christ, Maximilian Bellut, Sarah Gunkel, Christopher Karayiannis, John Ly, Shaloo Singhal, Lee‐Anne Slater, Young Dae Kim, Keon‐Joo Lee, Jae‐Sung Lim, Hideo Hara, Masashi Nishihara, Jun Tanaka, Masaaki Yoshikawa, Derya Selçuk Demirelli, Zeynep Tanrıverdi, Ender Uysal, Shelagh B. Coutts, Francesca M. Chappell, Stephen Makin, Henry Ka‐Fung Mak, Kay Cheong Teo, Debbie Y.K. Wong, Lisa Hert, Marta Kubacka, Philippe Lyrer, Alexandros A. Polymeris, Benjamin Wagner, Annaelle Zietz, Jill Abrigo, Cyrus Cheng, Chiu‐Wing Winnie Chu, Thomas Leung, David Seiffge, Urs Fischer, Simon Jung, Daniël Bos, Felix Fluri, Thanh G. Phan, Velandai Srikanth, Ji Hoe Heo, Hee‐Joon Bae, Yusuke Yakushiji, Dilek Neci̇oğlu Örken, Eric E. Smith, Joanna M. Wardlaw, Kui Kai Lau, Stefan T. Engelter, Nils Peters, Yannie Soo, Tae‐Jin Song, Robert Simister, David C. Wheeler, David J. Werring · 发表于：Neurology · 年份：2026 · DOI：10.1212/wnl.0000000000218406 · 被引用次数：1 · 研究领域：Cerebrospinal fluid and hydrocephalus、CNS Lymphoma Diagnosis and Treatment、Neurological Complications and Syndromes

BACKGROUND AND OBJECTIVES: Enlarged perivascular spaces (EPVSs) in the basal ganglia (BG-EPVS) are an important marker of cerebral small vessel disease (cSVD), and EPVS in the centrum semiovale (CSO-EPVS) are part of the diagnostic criteria for cerebral amyloid angiopathy. We aimed to investigate associations of EPVS with reduced estimated glomerular filtration rate (eGFR) and glomerular hyperfiltration (higher than normal eGFR), which have scarcely been studied previously. METHODS: , and glomerular hyperfiltration, defined as eGFR above the age-adjusted and sex-adjusted 95th centile, with BG-EPVS and CSO-EPVS severity. EPVS were rated according to a validated 5-point ordinal scale, and combined cSVD burden was rated using a validated 5-point ordinal scale with 1 point assigned for the presence of each of the following: severe white matter hyperintensities, ≥1 cerebral microbleed, ≥1 lacune, and BG-EPVS ≥11. Normal glomerular filtration was defined as eGFR ≥60 without hyperfiltration. We used multivariable ordinal logistic regression models to estimate risk of increased EPVS and cSVD burden severity adjusted for age, sex, and comorbidities. RESULTS: = 0.011). Associations of eGFR 30-60 and eGFR <30 with EPVS were not statistically significant. Compared with normal glomerular filtration, eGFR <30 (aOR 1.27, 95% CI 1.03-1.57) was independently associated with increased cSVD burden, but eGFR 30-60 (aOR 1.06, 95% CI 0.95-1.20) and hyperfiltration (aOR 1.15, 95% CI 0.98-1.34) were...