Mindfulness-based interventions for perinatal depression, anxiety, and stress: a systematic review and meta-analysis of randomized controlled trials, with an exploratory subgroup signal by delivery mode

作者：Gaoqin Tang, Unfai Cho, Jun Zhang, Min Chen · 发表于：Frontiers in Psychiatry · 年份：2026 · DOI：10.3389/fpsyt.2026.1868153 · 研究领域：Maternal Mental Health During Pregnancy and Postpartum、Mindfulness and Compassion Interventions、Music Therapy and Health

Background Perinatal depression is a highly common clinical complication. While expert panels advocate for non-pharmacological treatments, the relative benefits of mindfulness-based interventions delivered face-to-face versus through emerging digital platforms have not been examined within a single integrated synthesis that distinguishes the contribution of delivery mode from that of trial era and methodology. Methods We conducted a systematic review and meta-analysis of parallel-group randomized controlled trials evaluating mindfulness-based interventions for perinatal women. The synthesis relied exclusively on directly verifiable, publicly accessible study-level data, obtained from primary full-text reports and, for seven of the ten depression trials, from the open controlled-data table of a prior peer-reviewed meta-analysis (Lever Taylor et al., 2016). The primary outcome was post-intervention depressive symptoms, with anxiety and stress as secondary outcomes. A pre-specified subgroup analysis examined delivery mode (digital versus face-to-face) as an exploratory, hypothesis-generating moderator rather than as a head-to-head comparison. Results Ten RCTs (591 perinatal women) contributed depression data. MBIs significantly reduced depressive symptoms (Hedges g = -0.31, 95% CI -0.48 to -0.14; P < .001; I² = 0%), with a 95% prediction interval excluding the null. In an exploratory, pre-specified subgroup analysis, the digital subgroup showed a larger pooled effect than...