Supplementary Table S3 from Consistent Metabolomic and Genetic Evidence Supports Acisoga as a Key Contributor to Colorectal Neoplasia Progression

作者：Blanca Rius‐Sansalvador, Anastasia Chrysovalantou Chatziioannou, Pekka Keski‐Rahkonen, Nivonirina Robinot, Ferrán Moratalla-Navarro, Núria Moragas, Elisabet Guinó, Mazda Jenab, Francisco D. Morón-Duran, Carmen Atencia, Gemma Ibáñez‐Sanz, L. Rodriguez Alonso, Alfredo Mata Bilbao, Ana García‐Rodríguez, Hwayoung Noh, E Fryer, R. Zamora-Ros, Olatz Mokoroa, Iosu Delfrade, Saverio Caini, José María Huerta, Thérèse Truong, Gianluca Severi, Yazdan Asgari, ­Rosario ­Tumino, Salvatore Panico, Anne Tjønneland, Agnetha Linn Rostgaard‐Hansen, María‐José Sánchez, Valeria Pala, Fulvio Ricceri, Marc J. Gunter, Vı́ctor Moreno, Mireia Obón‐Santacana · 年份：2026 · DOI：10.1158/1055-9965.33143594 · 研究领域：Medicine、Internal medicine、Oncology、Bioinformatics、Physiology、Genetics

<p>Supplementary Table S3. Sensitivity analyses of Acisoga associations with CRC risk in the EPIC cohort stratified by tumour site, sex, and dietary factors. Odds ratios (OR) and 95% confidence intervals (CI) for CRC per 1 standard deviation (SD) increase in log-transformed metabolite levels are shown for three metabolic features corresponding to Acisoga-related ions and 248.0997@0.6454001. d stratification Sex, tumour anatomical site (proximal and distal colon), and tertiles (T1–T3) of dietary factors including red/processed meat intake, dietary fiber intake, and vegetable intake. Further models additionally adjusted for vegetable intake and dietary fiber intake. P-values for interaction were obtained from multiplicative interaction terms between metabolite levels and the corresponding stratification variable.</p>