Novel 2-amino-4-(1H-imidazol)pyridine derivatives as potent brain-penetrant EGFR mutant inhibitors: Design, synthesis, biological evaluation, and molecular modeling study

作者：Tingting Zhang, Shunli Peng, Yaqi Huang, Chunhui Huang, Zichao Yang, Yongxin Chen, Ying Jiang, Siming Liu, Shanhe Wan, Haikui Yang, Jiajie Zhang · 发表于：Bioorganic Chemistry · 年份：2026 · DOI：10.1016/j.bioorg.2026.110311 · 研究领域：HER2/EGFR in Cancer Research、Lung Cancer Treatments and Mutations、Synthesis and Reactivity of Heterocycles