Resting-State Brain Activity, Functional Connectivity, and Orbital Imaging Changes in Restrictive Myopathy Associated with Thyroid Eye Disease

作者：Haiyang Zhang, Zilin Fang, Duojin Xia, Songnan Liang, Yuwei Wang, Mengda Jiang, Xiaofeng Tao, Yinwei Li, Jing Sun, Xingtong Liu, Huifang Zhou · 发表于：Eye and Brain · 年份：2026 · DOI：10.2147/eb.s606171 · 研究领域：Ophthalmology and Eye Disorders、Vestibular and auditory disorders、Advanced Neuroimaging Techniques and Applications

Purpose: Restrictive myopathy is an important subtype of thyroid eye disease (TED) characterized by ocular motility restriction. Emerging evidence has indicated brain remodeling in TED restrictive myopathy, yet the underlying mechanism remains elusive. Therefore, this study aims to investigate brain activity and extraocular muscles (EOMs) abnormalities in TED restrictive myopathy, providing a deeper insight into the relationship between ocular motility restriction and brain functional changes. Patients and Methods: test was performed to compare intergroup differences, and correlation analysis was applied to uncover the association between brain functional activity and EOMs involvement. Results: TED restrictive myopathy exhibited increased intraocular pressure (IOP), long diameters (LD) and short diameters (SD) of inferior rectus, and decreased visual functioning score in Graves' orbitopathy-specific quality of life questionnaire (GO-QoL). Increased amplitude of low-frequency fluctuations (ALFF) in the left middle temporal gyrus (MTG.L) were found in TED restrictive myopathy. The functional connectivity (FC) analysis further discovered higher FC between MTG.L and the right cerebellum_8 and bilateral middle frontal gyrus (MFG). The brain imaging parameters were significantly correlated with vertical deviation, exophthalmos and EOMs metrics in TED restrictive myopathy. Conclusion: This study explored the brain alterations in TED restrictive myopathy, underscoring oculomotor rest...