Guiding functional near-infrared spectroscopy research on sedentary behavior and brain health.

作者：Jinming Li, Yanxia Chen, Yiming Tao, Z C Zhang, Qian Yu, Haijing Niu, Matthew Heath, Wei‐Peng Teo, Cassandra J Lowe, Sebastian Ludyga, Benjamin Tari, Mats Hallgren, Neville Owen, Boris Cheval, Stephane Perrey, Myrto Mavilidi, Fred Paas, MJ Campbell, Adam Toth, Felix Scholkmann, Uzair Hakim, Flaminia Ronca, Fabian Herold, Liye Zou · 发表于：Open Access CRIS of the University of Bern · 年份：2026 · DOI：10.48620/99784 · 研究领域：Optical Imaging and Spectroscopy Techniques、Physical Activity and Health、Health, Environment, Cognitive Aging

Background Excessive exposure to sedentary behavior (SB) is associated with cognitive decline and impaired brain health; however, the neurobiological mechanisms underlying this relationship remain unclear. Functional near-infrared spectroscopy (fNIRS) enables real-time monitoring of cerebral hemodynamics in naturalistic settings and offers unique technical advantages for understanding the effects of SB on brain health. Notably, methodological standardization specific to SB research is lacking, limiting cross-study comparisons and evidence synthesis despite established general fNIRS best practices.Methods Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically searched PubMed, Scopus, Web of Science, and PsycINFO through February 2026 for studies using fNIRS to assess SB's effects on brain function. Two independent reviewers conducted study selection, data extraction, and bias risk assessment. We systematically extracted and analyzed instrumentation specifications, spatial positioning, data processing pipelines, statistical methods, and quality control measures to identify methodological variations and best practice patterns in current research.Results From 36,477 initial records, 43 studies encompassing 2751 participants were included. Study types comprised acute (25 studies) and chronic interventions (8 studies) manipulating or monitoring SB patterns as well as cross-sectional studies (10 studies) analyzing the asso...