Association of hypothermic temperature-control duration at 33 °C with coagulation parameters after out-of-hospital cardiac arrest: a single-center retrospective cohort study

作者：Xiaogang Wang, Bo Jia, Xingsheng Wang, 秦永超, Le An, Chenchen Hang, X P Zhao, Rui Shao, Ziren Tang · 发表于：BMC Emergency Medicine · 年份：2026 · DOI：10.1186/s12873-026-01678-6 · 研究领域：Cardiac Arrest and Resuscitation、Thermal Regulation in Medicine、Sepsis Diagnosis and Treatment

The optimal duration of temperature control after out-of-hospital cardiac arrest remains uncertain. Prolonged hypothermic temperature control may affect coagulation, but clinical data remain limited. We evaluated the association between different durations of hypothermic temperature control at 33 °C and coagulation parameters, recorded clinical safety outcomes, and 6-month neurological outcomes in patients after out-of-hospital cardiac arrest. This single-center retrospective cohort study included 112 adult patients with out-of-hospital cardiac arrest who achieved return of spontaneous circulation and received hypothermic temperature control at 33 °C at Beijing Chaoyang Hospital from January 2018 to June 2024. Patients were grouped by actual maintenance duration: 24 h ( n = 39), 48 h ( n = 30), or 72 h ( n = 43). Coagulation parameters were measured serially. Recorded occult blood positivity, lower-extremity deep vein thrombosis detected by vascular ultrasonography, transfusion requirements, survival to discharge, and 6-month neurological outcomes were compared. Compared with the 24 h group, the 48 h and 72 h groups had longer activated partial thromboplastin time and lower platelet counts and D-dimer levels at corresponding time points. Thrombin time was prolonged in the 72 h group at 72 h. After FDR correction, statistically significant between-group differences persisted for APTT at 72 h and 96 h, TT at 72 h, D-dimer at 48 h, 72 h, and 96 h, and platelet count at 72 h and ...