Synaptic Plasticity Mechanisms Underlying Memory Formation in the Hippocampus

作者：Hailong Zhang · 发表于：Theoretical and Natural Science · 年份：2026 · DOI：10.54254/2753-8818/2026.au35376 · 研究领域：Neuroscience and Neuropharmacology Research、Memory and Neural Mechanisms、Sleep and Wakefulness Research

Synaptic plasticity is the biological basis of cognition used in building memories. Synaptic plasticity is a mechanism by which synapses vary in their strength with the degree of neural activity and it seems to be relevant to learning. Numerous studies have revealed that long term potentiation (LTP) is an important cellular process in forming memories in the brains of human beings. These kinds of mechanisms need to be understood in order to fill the apparent gap between behavioral memory and events occurring at the molecular level. The purpose of this project is to explore how NMDA/AMPA receptors modulate synaptic transmission through means of plasticity of the hippocampus, and to propose some hypothetical experiments, in which, once the synapses are canonically stimulated, the strength of the synapse can be measured. The results may help to support the general notion that memories are encoded in the brain's biological system through synaptic plasticity. This study could also furnish information pertaining to neurological disorders associated with memory dysfunctions, and possibly result in a greater insight into cognitive functions in various aspects.