A dual-lock strategy for tumor-specific pyroptosis activation plus gas synergism

作者：Wen Li, Haidong Li, Wen Li, 浩一 傅, Xiao Zhou, JeongYeon Hong, 浩一 傅, Yichu Yu, Shuang Zeng, Jingyun Wang, Juyoung Yoon, Xiaojun Peng · 发表于：Chemical Science · 年份：2026 · DOI：10.1039/d6sc04072a · 研究领域：Inflammasome and immune disorders、Immunotherapy and Immune Responses、Cancer Research and Treatments

released during activation further consumes GSH and amplifies the ROS storm, which ultimately triggers the caspase-3/GSDME-mediated pyroptosis pathway in tumor cells, remodels the immunosuppressive tumor microenvironment, and exerts potent therapeutic efficacy in tumor-bearing mouse models. This study not only exploits a new molecular platform for multimodal tumor theranostics, but also offers a safe and potent innovative strategy to precisely trigger tumor cell pyroptosis for high-efficiency cancer immunotherapy.