International phase IV field study to validate the European Organisation for Research and Treatment of Cancer questionnaire for assessing the health-related quality of life of cancer survivors: The EORTC QLQ-SURV100

作者：Louis Fox, Marieke van Leeuwen, Jennifer M. Jones, Amal Al‐Omari, Haneen Abaza, Muna Al-Khaifi, Martin Eichler, Sue M. Hartup, Galina Velikova, Nanna Fridriksdóttir, Juhee Cho, Nathalie Vanlaer, Anne Rogiers, Stefania Costi, Silvia Soncini, Trille Kristina Kjær, Volker Arndt, Daniela Doege, Ali Alkan, Hiroto Ishiki, Elke Rammant, Jannike Baumann, Marianne Sinn, Maria Antonietta Annunziata, Juan Ignacio Arrarás, Mieke Van Hemelrijck, Andrea Pace, Naomi Clatworthy, Victoria King, Lærke Kjær Tolstrup, Akihiko Shimomura, Meropi D. Kontogianni, Samantha Claire Sodergren, Nikolina Vukšić, Morten Aagaard Petersen, Jacobien Marije Kieffer, Michael Jefford, Tara Chalk, Teresa Young, Nayanaben Borda, Ofir Morag, Amelie Harle, Duška Petranović, Elena Meggiolaro, Silvia De Padova, Femke Jansen, Nazım Serdar Turhal, Chiara Maria Navarra, Ingo Baumann, Cecilie Delphin Amdal, Vassilios Vassiliou, Monica Pinto, Saiko Kurosawa, Ingvild Vistad, Muna Al-Balushi, A.A.G. Al Ghoche, Linda Dirven, Andreia Capela, Zeinab Elsayed, Sara Montemuiño, Patricia Willisch, Neil Aaronson, Lonneke V. van de Poll‐Franse · 发表于：European Journal of Cancer · 年份：2026 · DOI：10.1016/j.ejca.2026.116959 · 研究领域：Cancer survivorship and care、Frailty in Older Adults、Childhood Cancer Survivors' Quality of Life

INTRODUCTION: Cancer survivors face unique and persistent health-related quality of life (HRQoL) challenges. Existing HRQoL questionnaires for survivors lack content regarding chronic physical issues and have typically included limited cancer types and languages/cultures, affecting breadth of content and generalisability. We developed and validated the EORTC QLQ-SURV100, a questionnaire to assess HRQoL in disease-free survivors of diverse cancers. A conceptual framework of HRQoL in cancer survivors, developed in previous study phases and conceptualised as survivors' self-reported physical, mental and social functioning and well-being, formed the basis for questionnaire content. METHODS: The QLQ-SURV100 was administered to 1480 participants across 46 centres in 21 countries (31% breast cancer, 23% colorectal, 22% prostate, 24% other cancers), who had completed primary treatment 1-10 years earlier and had no evidence of active disease. Structural validity of the 21 multi-item questionnaire scales was assessed via confirmatory factor analysis; test-retest reliability via intraclass correlation coefficients (ICCs); construct validity through known-group comparisons; and cross-cultural validity and sex invariance through differential item functioning (DIF). Item response theory (IRT) analyses evaluated item redundancy and performance. RESULTS: The QLQ-SURV100 showed strong structural validity (Comparative Fit Index = 0.951; Tucker-Lewis Index = 0.944; Root Mean Square Error of App...