A Multilevel Deep Learning Model for Automated Brain Tumor Segmentation Using Magnetic Resonance Images

作者：Aneesh S. Perumprath, Kulandairaj Martin Sagayam, Syed Immamul Ansarullah, Muhammad Salim Khan, Sami Alshmrany, Farhan Amin, Isabel de la Torre Díez, Mirtha Silvana Garat de Marín, Eduardo Silva Alvarado · 发表于：Diagnostics · 年份：2026 · DOI：10.3390/diagnostics16142259 · 研究领域：Brain Tumor Detection and Classification、Advanced Neural Network Applications、Medical Image Segmentation Techniques

Background/Objectives: Brain tumor segmentation from magnetic resonance imaging (MRI) plays an important role in clinical assessment and treatment planning. However, accurate segmentation remains challenging because of the complex anatomical structure of the brain, variations in tumor size and shape, and the imbalance between tumor and non-tumor regions in MRI datasets. These challenges highlight the need for reliable automated segmentation methods. Methods: This study proposes a multilevel deep learning model for automated brain tumor segmentation using MRI images. The BraTS dataset was used for model development and evaluation. To address class imbalance, a modified Synthetic Minority Oversampling Technique (SMOTE) was incorporated during preprocessing. A Multilevel Architecture-Based Modified U-Net was then employed to learn multiscale spatial features and generate pixel-wise tumor segmentation. The proposed framework was evaluated using the Dice coefficient, Jaccard coefficient, Matthews Correlation Coefficient (MCC), and accuracy. Results: The experimental results demonstrate that the proposed model consistently outperformed the Berkeley Wavelet Transform (BWT)-based method and the conventional U-Net across different tumor grades. Higher Dice, Jaccard, and MCC values indicate improved agreement between the predicted segmentation and the expert-annotated ground truth masks, demonstrating more accurate and consistent tumor delineation. Conclusions: The proposed multilevel ...