Bidirectional Mendelian randomization of gut microbial traits and erectile dysfunction with cross-cohort same-SNP evaluation and multiplicity control

作者：Xiancheng Du, Shuchun Tao, Kaihua Xue, Yongkun Zhu, Yihan Shi, Hang Gu, Ming Chen, Chunhui Liu, Chao Sun · 发表于：Open MIND · 年份：2026 · DOI：10.5281/zenodo.21456670 · 研究领域：Medicine、Biology、Immunology、Bioinformatics、Genetics、Internal medicine

Reproducible code, frozen primary outputs, derived explanatory audits, provenance records, final supplementary materials, and submission-grade figures for a bidirectional Mendelian randomization reassessment of gut microbial traits and erectile dysfunction. Primary eligibility and multiplicity criteria were defined before screening. Cross-trait LD compression and exact-rsID phenotype annotation were targeted post hoc audits restricted to frozen alternative-outcome signals. HUNT provides an independent exposure cohort for same-SNP evaluation, not independent MR replication. Third-party GWAS payloads are not redistributed.