Short-Term Effects of PM2.5 Exposure on Hematological and Biochemical Blood Indices in the Middle-Aged and Elderly

作者：Chi-Thien Dinh, Hsiao‐Chi Chuang, Huan Minh Tran, Y F Wang, Yuan-Chien Lin, Thu Vo-Pham-Minh, Chien-Hua Tseng, Chien-Ling Su, Kang‐Yun Lee, Tzu-Tao Chen, Kian Fan Chung, Kin-Fai Ho, Kai-Jen Chuang, Jer‐Hwa Chang · 发表于：Aerosol and Air Quality Research · 年份：2026 · DOI：10.1007/s44408-026-00131-4 · 研究领域：Air Quality and Health Impacts、Health, Environment, Cognitive Aging、Antioxidant Activity and Oxidative Stress

Air pollution has been associated with respiratory and cardiovascular diseases; however, its effects on routinely measured blood indices remain incompletely understood. This study examined associations between short-term particulate matter with an aerodynamic diameter of 2.5 μm or less (PM 2.5 ) and hematological and biochemical indices in middle-aged and older adults. A study involving 989 adults aged 40 years and older, recruited from the community in Taiwan from 2018 to 2022, assessed hematological (erythrocyte, leukocyte, and thrombocyte) and biochemical (electrolyte levels, renal function, glycemic control, hepatobiliary function, lipid profile, and iron status) indices. PM 2.5 exposure over 1-day, 7-day, and 1-month periods was estimated to evaluate both immediate and lagged effects. Associations between PM 2.5 and blood indices were explored employing linear regression models, adjusted by age, sex, body mass index, smoking status, vegetarian diet, relative humidity, temperature, work status, exercise habits, and comorbidities. Higher PM 2.5 exposure was associated with changes in several hematological and biochemical indices, including lower hematocrit, mean platelet volume, sodium, calcium, magnesium, creatinine, albumin, and iron, and higher mean corpuscular hemoglobin concentration, red cell distribution width, monocytes, and total bilirubin. The magnitude of the effects increased as the exposure period lengthened. Associations were generally more frequent among par...