Supplementary Figure S3 from Neoadjuvant Stereotactic Body Radiotherapy plus Immune Therapy Favorably Remodels the Hepatocellular Carcinoma Tumor Microenvironment

作者：Zoe L. Cosner, Zhoubo Guo, Cole Nawrocki, Bidish K. Patel, Hannah Roberts, Kenneth K. Tanabe, Kelsey S. Lau‐Min, Elizabeth Walsh, Jeffrey W. Clark, Motaz Qadan, Cristina R. Ferrone, Theodore S. Hong, Linda T. Nieman, David T. Ting, Jennifer Y. Wo, Joseph W. Franses · 年份：2026 · DOI：10.1158/1078-0432.33014514 · 研究领域：Medicine、Cancer research、Oncology、Internal medicine、Pathology

<p>Fig. S3. Cell type composition and comparative analyses. (A) UMAP of cells colored by collapsed cell type and split by slide. (B) Proportions of cell types across individual samples. (C) Comparison of macrophage subtype scores (M0, M1, and M2) between postTx and TxN groups. Scores were calculated using gene module scoring, and statistical significance was assessed using two-sided Wilcoxon rank-sum tests. (D) Immune cell enrichment, defined as the ratio of immune cells to tumor cells. (E) Differential gene expression between postTx and TxN samples in macrophages, tumor cells, endothelial cells, fibroblasts, T cells, B cells, and plasmablasts, visualized as volcano plots. (F) Treatment responses of patients corresponding to the single cell spatial transcriptomic samples.</p>