High Resolution MHC Sequencing Reveals Novel Genetic Risk Variants Underlying Antithyroid Drug-Induced Agranulocytosis

作者：Xinyao Miao, Yiqi Jiang, 明晶 趙, Yi Luo, Xiaojuan Gon, Xin Guo, Bowen Tan, Chunxia Yan, B Zhang, Shuaicheng Li, Yayi He · 发表于：Figshare · 年份：2026 · DOI：10.6084/m9.figshare.33005669 · 研究领域：Biology、Genetics、Computational biology、Medicine、Bioinformatics

This dataset contains the supplementary materials for the manuscript "High Resolution MHC Sequencing Reveals Novel Genetic Risk Variants Underlying Antithyroid Drug-Induced Agranulocytosis" by Miao et al., submitted to The Journal of Clinical Endocrinology & Metabolism.Contents: Supplementary Methods and Results;Supplementary Figures S1-S6;Supplementary Tables S1-S13.These materials provide detailed methodological information, additional statistical analyses, and extended data supporting the findings reported in the main manuscript.Key supplementary data include quality control metrics for MHC-targeted sequencing, linkage disequilibrium plots of TIA-risk SNPs, genotype-haplotype patterns in the TSBP1-AS1~HLA-DRA intergenic region, PRISMA flow diagram for meta-analysis, hierarchical clustering of cohort-related HLA alleles, PC-adjusted association summary and Firth penalized logistic regression results, clinical and treatment parameters of TIA cases and GD controls, sequencing summary and genotyping consistency comparisons, genotype and allele frequency of 12 tag TIA-risk SNPs, logistic regression results for genetic factors associated with TIA, serum C4 level records, sensitivity analysis excluding PTU-treated case, regression analysis of HLA-C*07:02 allele dosage effect on severity, summary data for meta-analysis of HLA-B*38:02, HLA-B*39:01, and HLA-DRB1*08:03, exploratory analysis of ATD dose, and PPV recalibrated to realistic TIA prevalence.These supplementary material...