Supplementary Figure S4 from Neoadjuvant Stereotactic Body Radiotherapy plus Immune Therapy Favorably Remodels the Hepatocellular Carcinoma Tumor Microenvironment

作者：Zoe L. Cosner, Zhoubo Guo, Cole Nawrocki, Bidish K. Patel, Hannah Roberts, Kenneth K. Tanabe, Kelsey S. Lau‐Min, Elizabeth Walsh, Jeffrey W. Clark, Motaz Qadan, Cristina R. Ferrone, Theodore S. Hong, Linda T. Nieman, David T. Ting, Jennifer Y. Wo, Joseph W. Franses · 年份：2026 · DOI：10.1158/1078-0432.33014511 · 研究领域：Medicine、Cancer research、Pathology、Oncology、Internal medicine、Immunology

<p>Fig. S4. Spatial localization of immune aggregates. (A) Spatial distribution of immune aggregates in TMA1, TMA2, HCC1, HCC2, HCC3, HCC4, and HCC5 slides. Red dots indicate cells within immune aggregates; gray dots represent other cells. Red boxes indicate tumor FOVs, green boxes indicate normal liver FOVs, purple boxes represent both FOVs (containing both normal liver regions and malignant cell regions), and gray boxes indicate other FOVs. (B) Comparison of immune aggregate size between the TxN and postTx groups, with size defined by the number of constituent cells. (C) Comparison of cellular composition between FOVs containing immune aggregates (IA FOVs) and FOVs without immune aggregates (Non-IA FOVs) in the TxN and postTx groups. (D) Cellular composition of tumor margin immune aggregates (IA-margin) and intratumoral immune aggregates (IA-tumor) in the postTx group.</p>