Multiparatopic antibodies overcome tyrosine kinase inhibitor resistance by inducing lysosomal degradation of EGFR mutants

作者：Chunjie Lin, J Liu, Jiacheng Ni, Dingrui Chen, Ying Liu, Wanyinhui Zhu, Yinuo Sheng, Yunling Wang, Gao Y, Xicheng Zhang, Weirui Ma, Yaoji Liang, Deli Huang · 发表于：Oncogene · 年份：2026 · DOI：10.1038/s41388-026-03901-x · 研究领域：Monoclonal and Polyclonal Antibodies Research、HER2/EGFR in Cancer Research、Toxin Mechanisms and Immunotoxins