Association of lipid metabolism and musculoskeletal fatty infiltration with the risk and severity of osteoporotic vertebral compression fractures in postmenopausal women: A retrospective study

作者：Zhu Yihua, Qian Cheng, Qitai Wu, Jiaxin Liu, Wumiti Taxi, Tianchi Zhang, Qinfeng Zhou, Kaixuan Wang, X Q Chen, C F Wang, Yang Guo, Yong Ma, Lining Wang · 发表于：Journal of Back and Musculoskeletal Rehabilitation · 年份：2026 · DOI：10.1177/10538127261468079 · 研究领域：Bone health and osteoporosis research、Hip and Femur Fractures、Spinal Fractures and Fixation Techniques

Objective This study aimed to investigate the associations of multi-dimensional lipid metabolism indicators, comprising serum lipid profiles and the degree of fatty infiltration in the musculoskeletal system, with bone mineral density (BMD) and bone turnover markers (BTMs), and to identify independent risk factors for the occurrence and severity of osteoporotic vertebral compression fractures (OVCFs) in postmenopausal women. Methods This retrospective study included a total of 133 postmenopausal women from January 2023 to July 2024. Participants were stratified by fracture status and vertebral compression severity. Clinical data, including bone and lipid metabolic indicators and BMD, were retrieved from electronic medical records and MRI reanalysis. Pearson correlation analyzed associations between lipid metabolic indicators and BTMs/BMD. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for OVCFs, with multicollinearity among variables assessed using the variance inflation factor (VIF), and ordinal logistic regression was applied to assess lipid metabolic indicators’ impact on vertebral compression severity. Statistical analyses included Student's t-test or Mann-Whitney U test for group comparisons and one-way analysis of variance (ANOVA) for multiple-group comparisons. Result This study included 133 participants: 34 controls, 32 with mild, 38 with moderate, and 29 with severe fractures. Age, BMI, BMD, vertebral bone...