Anti-inflammatory Diet Before Diagnosis and Survival After Urologic Cancer: Findings from Two Swedish Prospective Cohorts

作者：Tahir Taj, Katja Fall, Samia Shahid, Henrik Ugge · 发表于：European Urology Open Science · 年份：2026 · DOI：10.1016/j.euros.2026.06.008 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Bladder and Urothelial Cancer Treatments、Inflammasome and immune disorders

Background: Dietary patterns with anti-inflammatory properties have been linked to lower risks of several chronic diseases and some cancers, but their impact on survival after cancer is less well understood. Objective: We assessed whether a higher prediagnostic Anti-Inflammatory Diet Index (AIDI) score was associated with all-cause mortality after urologic cancer diagnosis, with urologic cancer-specific mortality evaluated as a secondary end point. Design setting and participants: In the Cohort of Swedish Men and the Swedish Mammography Cohort, incident urologic cancers and deaths were identified through Swedish registers. AIDI was derived from food-frequency questionnaires (1997; 2009 in a subset) and defined as the assessment at least 2 yr before diagnosis, preferentially 2009 when available. Follow-up ran from diagnosis to death, emigration, or December 31, 2020. Outcome measurements and statistical analysis: Cox models estimated hazard ratios (HRs) per 1 standard deviation (SD) higher AIDI, adjusting for demographic factors, lifestyle, comorbidities, and total energy intake. Fine-Gray models assessed urologic cancer-specific mortality while accounting for death from other causes as a competing event. Results and limitations: Among 7686 patients with valid AIDI, 6609 had complete covariate data, including 4990 patients with prostate cancer. During follow-up, 3281 deaths occurred, including 1435 urologic cancer deaths. Each 1-SD higher AIDI was associated with lower all-cau...