Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis

作者：Heather M. Wastler, Aubrey M. Moe, Alexandra M. Blouin, Melanie Bozzay, Melissa F V Kilicoglu, Celso Arango, Sylvain Bouix, Matthew R. Broome, Monica E. Calkins, Philippe Conus, Cheryl M. Corcoran, Courtney Crawford, Covadonga M. Díaz‐Caneja, Stefano Damiani, Paolo Fusar‐Poli, Matcheri S. Keshavan, Vijay A. Mittal, Josh Nguyen, Jason Schiffman, Jai Shah, Walid Yassin, Alison Yung, Jean Addington, Luis Alameda, Kristin S. Cadenhead, Ricardo E. Carrión, Rolando I Castillo-Passi, Eric Chen, Jimmy Choi, Barbara A. Cornblatt, Lauren M. Ellman, Pablo A Gaspar, Carla Gerber, Louise Birkedal Glenthøj, Leslie E. Horton, Christy Lai Ming Hui, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Minah Kim, Sung‐Wan Kim, Nikolaos Koutsouleris, Jun Soo Kwon, Kerstin Langbein, Daniel Mamah, Daniel H. Mathalon, Merete Nordentoft, Godfrey D. Pearlson, J. Perez Perez, Diana O. Perkins, Albert R. Powers, Jack Rogers, Fred W. Sabb, Steven M. Silverstein, Stefan Smesny, William S. Stone, Gregory P. Strauss, Judy L. Thompson, Rachel Upthegrove, Swapna Verma, Jijun Wang, Daniel H. Wolf, Tianhong Zhang, Ofer Pasternak, René S. Kahn, Martha E. Shenton, Patrick D. McGorry, Barnaby Nelson, John M. Kane, Carrie E. Bearden, Scott W Woods, Accelerating Medicines Partnership Schizophrenia, Lauren Addamo, Uzair Ahmed, Kelly Allott, Mario Álvarez‐Jiménez, G Paul Amminger, Rosie Arnold, Rebecca Beedham, Coco Beylot, Anusha Bharal, Sonia Birch, Kate Buccilli, Elle Butterworth, Eloise Cameron, John Chen, Ann Ee Ching, Beau-Luke Colton, Kate Conroy, Brittany Cook, Frederica Cooke, Simon D’Alfonso, Thomas Digby, Dominic Dwyer, Melanie Formica, Caroline Gao, Carmela Germano, Ruth Getachew, Larry Hendricks, Kevin Huynh, Sarah Joseph, Melissa Kerr, Wing Hei Lam, Mahlee Langdon, Suzie Lavoie, Clarice Lee, Joshua Llerena, Patrick D. McGorry, Brittany McQueen, Yohannes Mebrahtu, Inge van Meurs, Genevieve Middleton, Neal Morrell, Adibah Amani Nasarudin, Barnaby Nelson, Elle Nguyen, Josh Nguyen, Sally O’Callaghan, Mariam Omar, Alice Partridge, Christina Phassouliotis, Matthew Phung, Andrea Polari, Marta Radosevic, Kate Reynolds, Keita Rudd, Shaheen Samnani, Isabelle Scott, Romy Schaumann, Angela Scheppokat, Raushaan Seychell, Amber Sherriff, Jashmina Shetty, Callum Snowball, Jessica Spark, Holly Still, Andrew Thompson, Michael Thwaites, Sophie Tod, Matilda Tonkovic, Cassandra M J Wannan, Thomas J. Whitford, Sarah Whitson, Scott Williams, Stephen J. Wood, Rochelle Ruby Ye, Sarah Youn, Hok Pan Yuen, Alison R. Yung, Scott R. Clark, Marlene Früh, Igor Izyurov, Juliane Korittnik, Kerstin Langbein, Veronique Mann, Constantin Siegert, Stefan Smesny, Frederick Tekook, Helle Gade Andersen, Anne Sofie Abildskov Dahl, Bjørn H. Ebdrup, Nikoline Rolver Elk, Anna Feveile, Louise Birkedal Glenthøj, Kristina Ballestad Gundersen, Ulrich Lindberg, Anne Karen Nielse, Merete Nordentoft, Helle Schæbel, Mikkel Erlang Sørensen, Sofie Amalie Ege Sørensen, Daban K A Sulaiman, Matthew R. Broome, Chloe Clifford, Elizabeth Farrow, Paul Hicks, Dechante Johnson, Aanya Malaviya, Aissata Mavambu, Jack Rogers, Rachel Upthegrove, Luis Alameda, Yasser Aleman, Livia Alerci, Marco Armando, Morgane Baumgartner, Martine Cleusix, Caroline Conchon, Philippe Conus, Kim Q Do, Khadimallah Ines, Raoul Jenni, Anastasie Jordan, Paul Klauser, Emylène Ostertag, T. Petrova, DaHye Jeon, Anna Jo, Sung‐Wan Kim, MiYoung Lee, ChaeWon Park, JiMin Yoo, Mei San Ang, Yi Chian Chua, Darshan Dahjalarrajah, Hui En Lisa Koh, Jue Xin Janice Koi, Bing Cai Kok, Jia Ming Lau, Jimmy Lee, Voon Hao Lew, Yu Juan Lim, Siwei Cisy Liu, Wen Liang Loh, Amirah M Iskandar, Kwun Kei Eric Ng, Gurpreet Rekhi, Nathanael Tang, Yu Zheng Charmaine Tang, Yinghui Teng, Sin Yi Joice Tham, Pushpalata Tharumalingam, Swapna Verma, Jie Yin Yee, Hui Hui Michelle Yeo, Yichi Zhang, Juan Helen Zhou, Candice Yu Hay Chan, Eric Chen, Lai Ming Christy Hui, Sonia Suet Ching Lo, Hui Lam Ng, Melody So, Yi Nam Suen, Ming Fung Tang, Tsz Lam Miriam Yeung, Öznur Baştürk, Annkathrin Böke, M Chakraborty, Sophie Fengler, Lana Kambeitz-Ilankovic, Joseph Kambeitz, Sophie Müller, Julian Wenzel, Tatiana Adasme, Alejandro Bruna, Rolando I Castillo-Passi, Pamela Contreras, Sebastián Corral, Pablo A Gaspar Ramos, Alejandro Maturana-Hurtado, Rocío Mayol-Troncoso, Pamela Paz, Manuel Reyes, Cesar Salinas, Gabriel Turra-Fariña, Daniela Valle, Francisco Zamorano, David Cotter, David Mongan, Jessica Hartmann, Naomi Wray, Hanneke Wigman, Laura L Adery, Carrie E. Bearden, Monica Done, Gil D. Hoftman, Dylan Hughes, Kristen Laulette, Bernalyn Ruiz‐Yu, Jamie Zinberg, Rui Ma, Jennifer Betancourt, Vardui Grigoryan, Sparsh Moondhra, Vanessa Calderon, Simon Kapler, Katherine Karlsgodt, Andrea Vazquez Espinosa, Daisy Lopez, Oliver Flores, Misty C Richards, Debha Amatya, Danielle Denenny, Seohyun Joo, Sheena Salonga, Emily Martinez, Rachel McKinney, Jared Gilbert, Sergio Duron, Maria Golchin, Lorena Ruvalcaba, Grace Cai, Zachary Wong, Neda Awad, Daisy Lopez, Tanya Diaz, Mary Rshtouni, Meghan Kussman, Monica Espana-Velasquez, Sullivan Salone, Wendy Zhang, Victoria Rosén, Lauren Trinidad, Alexis Worthley, Angela Jin, Remy Noveshen, Lisa Bartolomeo, Juliet Hagar, Haley Wang, Katherine Byrne, Rhideeta Jalal, Jee Won Kang, Masha Kotlyarevskiy, Dinisha Mingo, Arianna Mordy, Lingyan Yu, Brittney Sy, Petra Rupert, Melodie Yen, Brittany Wolff, Ella Bogomilsky, Carla Gerber, Fred W. Sabb, Carli Smythe, Nicole Swann, Meghan Davis-Reyes, Brett Barnes, Kelsey Schultz, Alexander Rockhill, Caghain McCoy, Daniel Brown, Jolinda Smith, Apoorva Karekal, Vince Quesada, Alex Holmes, Coleen Hudkins, Nicolas R. Bolo, Andrew Byun, Matcheri Keshavan, Erlend Lane, Jane Mikkelson, Carsten Langholm, Setari Parsa, Gennarina Santorelli, William S. Stone, John Torous, Michelle Friedman-Yakoobian, Camille Evans, Walid Yassine, Highsmith Rich, Nikita Bansal, Margret Niznikiewicz, Lynda Tucker, Colette Potts, Danielle Larsen, Debra Tolstonog, Kalina Sabeva, Courtney Crawford, Siyan He, Siyu Li, Olivia Aveson, Raquelle Mesholam-Gately, Jean Addington, Amy Shalev, Araba Chintoh, Bradley Goodyear, Cari Jahraus, Emma Truscott, Erin Jones, Lu Liu, Karl Jungert, Monica Chu, Paul Romo, Amanda Chao, Dominique Bonneville, Jacqueline Stowkowy, Kali Brummitt, Kristin Minara, Ruth Olsen, Timothy Michaels, Xiang He, Michael Birnbaum, Mitchell Arnovitz, Andrea Auther, Ricardo E. Carrión, Barbara A. Cornblatt, John M. Kane, Patricia Marcy, Priya Matneja, Danielle McLaughlin, Susan Ray, Lauren Serrano, Nilda Rivera-Reyes, Rachel F Bleggi, Clark D Jeffries, Diana O. Perkins, Jenna Barbee, Sree Gogineni, Abigail Shuman, Amanda Neal, Cecilia Pearson Sousa, Daphney Bryan, Earl McBride, Elena Pokowitz, Rohan Kumar, Amber Leinward, Ayşenil Belger, Brittany Weir, Calli Holshouser, Camila Vallebona, Christian Santos, Daniel Kutuzov, Emily Hammer, Idil Baran, Jennifer Nieri, Karen Ecsedy, Nicholas Sheppard, Rachel Bleggi, Shreeya Yarlagadda, Soliha Norbekova, Victor Pincay, Erica Oake, Averi Goldman, Emilie Powell, Marissa Mulea, Asher Alexander, Ewa Zapala, Jasper Mark, Sevde Aksoy, Erika Allison, Claire Deen, Anjali Chandrasekhar, Aidan Blumsack, Eliza List, Catherine Spencer, Danielle Pratt, Franchesca Kuhney, Gabrielle Olson, Isabelle Frosch, Ivanka Ristanovic, Jessica Fattal, Joanna Hernandez, Julie Kwon, Katherine Damme, Luz Maria Alliende Serra, Madison Stevens, Sophia Parmacek, Stew Shankman, Trevor Williams, Vanessa Zarubin, Vijay Mittal, Trevor Williams, Cameron Martinez, Chloe Krugel, Erica Karp, Gillian Ho, Jadyn Park, Juston Osborne, Kathy Moran, Kelly Bates, Maksim Giljen, Zachary Anderson, Kristin S. Cadenhead, Jiayi Lin, Vereena Metry, Leda Kennedy, Heline Mirzakhanian, Chérine Akkari, Tyrone D. Cannon, Youngsun Cho, Nicole Santamauro, Kangjoo Lee, Masih Rahmati, Jie Lisa Ji, Catalina V Mourgues, Ángela Núñez, Munaza Ali, Alan Anticevic, Clara Fonteneau, Karlos J Mate Piovanetti, Holly Enden, JENNA GANNON, Brandon Asika Etuka, Godfrey D Pearlson, Albert R I I I Powers, Vinod H. Srihari, Zailyn Tamayo, Emily Farina, Mara Heneks, Samuel Brege, Barbara C. Walsh, Scott W Woods, Alvaro Granados, Seyenah Lopez, Terry Camarro, John Cahill, Holly Hamilton, Daniel H Mathalon, Spero C Nicholas, Lenie Torregrossa, Renée Dembo, Zoë Rygg, Annalise Jear, Stephanie Haft, Emily Parsons, Cindy Herrera, Marvin Ruan, Cassandra Marzke, Janet Hwang, Sarah Eteminan, Frederikke Elnegaard, Chi Cheng Lao, Paul A Betancourt, Akemi Mii, Chris Perry, Brian Roach, Stephanie Stiavetti, B. Stuart, Alexandra Barnes, Alyssa Bathery, Monica E. Calkins, Ruben C. Gur, Ruben C Gur, Irena Kesselring, Christian G. Kohler, David R. Roalf, Kosha Ruparel, Sage Rush, Chloe Savage, Bruce I. Turetsky, Daniel H. Wolf, Eirini Zoupou, Julia Milkins, Lily Savage, Natalia Sonsin-Diaz, Eli Kales, Naomi Shifman, Nick Wellman, Nicole Kim, Allison Port, Alexandria Selloni, Dewey Chu, Gaurav Verma, Margaret Garret, Muhammad Parvaz, Riaz Shaik, Shaynna Herrera, Yulia Landa, Daniel Sauermilch, Byron Ramirez, Violet (Jingyi) Yang, Tahlya Holness, Elizabeth Ray, Pojen Deng, Meghana Gogineni, Qiwen Gu, Abigayle Fogarty, Katherine Dokhoylan, Elana Gabriel, Ronit Shvarzman, Agrima Srivastava, Angela Lu, Antigone Phili, Cansu Sarac, Conrad Musey, Ezra Ellenberg, Jane Gorman, Julia Norman, Matthew Cotter, Maxwell Mikelic, Nahal Talasazan, Sophia Shuster, Zachary Bergson, Nicole Hays, Lea Erjavc, Cheryl M Corcoran, Rene S Kahn, Alessia McGowan, Abraham Reichenberg, Agrima Srivastava, Inge Winter-van Rossum, Tina Gupta, Leslie E. Horton, Rebecca McIlhenny, Christian Porter, Charise Peters, Dean Salisbury, Emma Headley, Fabio Ferrarelli, Hannah Kirsch, Maria Jalbrikowski, Megan Deam, Thomas, AnaKarina Villa, Salsabil Gehan, Syndey Barlow, Sara McNemar, Lauren M. Ellman, Kyle S. Kinney, A McDonnell, Joshua Mervis, Vishnu Murty, Raana Mohyee, Stephanie Korenic, Ian Ogborn, Brennan Burns, Emily Lipner, Rachel Furlan, Anjani Ningaiah, Blake Elliot, Bry Estupinan, Ellen Whitton, Emma Smith, Jacqueline Wurman, Jay Hope, Katey O'Brien, Lily Towle, Madeline Pike, Nina Bertolami, Olivia Garces, Riley Capizzi, Shelby Tkacik, Thomas Olino, Vishnu Murty, Zeeshan Huque, Ranesh Mopuru, Raayana Arora, Johanna M Jarcho, Zarina Bilgrami, Tae'lar Henry, Linying Li, Elaine Walker, P. de Wolff, Gregory P. Strauss, Ashley Zollicoffer, Delaney Collins, Gifty Ayawvi, Lauren Arnold, Lauren Jennings, Lisa Bartolomeo, Luyu Zhang, Melissa McDowell, Sierraann Jarvis, Stephanie Croyle, Sydney James, T J Hardy, Zachary Carter, Zhixin Zhang, Masoomeh Faghankhani, Michael P. Harms, Daniel Mamah, Aakash Patel, Andrey Anokhin, Jacob Woessner, Joshua Shimony, Leonard Imbula, Malana Kanallakan, Megan Sneed, Semyon Golosheykin, ShingShiun Chen, Ginger Nicol, Alaina Yarber, Ashley Meyer, Janine Bijsterbosch, Jerome Nashed, Miranda Smith, Ozlem Korucuoglu, Rebekka Hakestad, Reza Hamidian, Shalaka Nimmagadda, Shayna Rosen, Yazen Al-Hosni, Christina Pritchard, Lisa Callison, Ruben Ybarra, Adrian Preda, Alison Boos, Brandi Rollins, Elizabeth Martin, Emily Petti, Jason Schiffman, Karen Coronado, Madeline Snyder, Maksim Giljen, Mia Villegas, Miranda Bridgwater, Theo van Erp, Yerim Ryu, Lindsay Healey, Monica Esquer, Hannah Moring, Marco Maldonado, Michelle Zernick, Arlene Dominguez, Ceouna Hegwood, Angelo Richardson, Deirdre von Pechmann, Diana King, Godfrey D Pearlson, Jadwiga Collen, Jennifer Scagliotti, Jennifer Zajac, Jesse Charpentier, Michael Stevens, Patricia Graham, Russell Starankewicz, Sara Putala, Isabelle Genereux, Elizabeth Hendry, Caitlyn Begley, Jimmy Choi, Aarti Kotecha, Laci-Ann Mosher, Frescia Velarde, Samantha Aversa, M Mallar Chakravarty, Martín Lepage, Rachel A. Rabin, Jai Shah, Elissa Zavaglia, Brianna Beesley, Fjolla Berisha, Joelle Eid, Xing Dai, Felicia Proteau-Fortin, Joseph Ghanem, Diana Berjaoui, Gareth Barker, Matthew; id_orcid 0000-0003-3541-9947 Kempton, Candida Vasconcelos, Andrea DeMicheli, Tom Spencer, Amedeo Minichino, Sébastien Brodeur, Ilaria Toniol, Andrés Estradé, Paolo Fusar-Poli, Sarah Kerins, Renato Borgatti, Stefano Damiani, Martina Maria Mensi, Anna Pichiecchio, Pierluigi Politi, Umberto Provenzani, Ilaria Bonoldi, Paolo Fusar-Poli, Celso Arango, Covadonga M. Díaz‐Caneja, Álvaro Andreu-Bernabeu, Adrian Capllonch, Ana Sanchez-Camara, Santiago Gil-Molina, Isabel Morales, Celia Ordás, Hayford Abrokwa, Joaquín Galvañ, Julio Prieto-Montalvo, José Suárez-Campayo, Maria Lucas, Marta Sepúlveda-Palomo, Jessica Merchán‐Naranjo, Pablo Andrés‐Camazón, Raquel Rodriguez, Juan Álvarez‐Linera, Vito Cavone, Sandra Recio, Ana Echevarria, Violeta Casas, Rebeca Toledano, Miriam Ayora, Renzo Abregú-Crespo, Teresa Bollain, Liliana Galindo, J. Perez Perez, Harri Allan, Izabele Batkovskyte, James Hughes, Julia Szacilo, Laura Stolp, Nicola Marshall, Tristan Bekinschtein, Vicky Lupson, Lucy Slade, Ben Cook, Nikolaos Koutsouleris, Alexandra Tchinitchian, Anne Ruef, Beate Dornheim, Caroline Plett, Christopher Eberle, Clara Weyer, Daniel Keeser, John Fanning, L. Neuner, Nadia Bieler, Nicole Obermuller, Oliver Pogarell, Peter Zill, Ronja Stohmann, Sabine Sirch, Sylvia de Jonge, Maria Urquijo, Elif Sarisik, Nestor Germanos, Jun Soo Kwon, Eugenie Choe, Harin Oh, Inkyung Park, Minah Kim, MinJi Ha, Sang Jee Rhee, Sunah Choi, Ji Seon Jang, Nayoung Sung, Heera Kim, Sunghyun Park, Jun Seo Hwang, Moonyoung Jang, Sori Kim, Hyungyou Park, Jong Rak Kim, Jungha Lee, Jiwon Son, Yeonjin Lee, Cho Won Ham, Dongjin Shin, JongWhan Kang, Sulim Jeong, Sumin Yeo, SuYong Lee, TakWan Kim, Won Lee, Woori Choi, WuJeong Hwang, YooBin Kwak, Yurim Shim, SuJin An, Nicholas J K Breitborde, Ivy F Tso, Jessica A Turner, Heather M. Wastler, Nancy Lundin, Sarah Hamilton, Cassandra Hennes, Vindhya Srikanth, Nichole Storey, Raffles (Henry) Cowan, Catherine Baughman, Alexandra Blouin, Aubrey Moe, Craig Parris, Sydney Craig, Callie Orme, Walter Stearns, Hossam Guigis, Amanda Kostayak, Judy L. Thompson, Steven M. Silverstein, Brittany Blose, Clifton Miller, Iwona Juskiewicz, Lyvia Bertolace, Madalina Tivarus, Pamela Zachary, Susan Wall, Tsion Eshetu, Dominic Oliver, Ameneh Asgari-Targhi, Adrianna Belskis, Tashrif Billah, Owen Borders, Lisa Brown, Evan Gentis, Dylan Campbell, Holly Carrington, Suheyla Cetin-Karayumak, Kelly Hay Yee Chan, Kota Chin, Kota Chin, Kang Ik K Cho, Michael J. Coleman, Shreyas Fadnavis, Anastasia Haidar, Grace R Jacobs, Omar John, Tina Kapur, Sinead Kelly, Nicholas Kim, Elana Kotler, Marek Kubicki, Maria Loy, Dheshan Mohandass, Lipeng Ning, Ofer Pasternak, Nora Penzel, Nicholas Prunier, Yogesh Rathi, Hannah Reiter, Caitlin Ridgewell, Johanna Seitz‐Holland, Martha E. Shenton, Mark Vangel, Simone Veale, Alana Wickham, Justin T Baker, Yoonho Chung, Habiballah Rahimi Eichi, Michaela Ennis, Kathryn E. Lewandowski, Einat Liebenthal, Eric Lin, Beier Yao, Cheryl M Corcoran, Rene S Kahn, Alessia McGowan, Abraham Reichenberg, Agrima Srivastava, Inge Winter-van Rossum, Sylvain Bouix, Robert J Glynn, Alicia Martín, Felecia Cerrato, Adrianna Maglieri, Lerato Majara, Mathias Goncalves, Christopher Markiewicz, Russell A. Poldrack, Gregory A. Light, Daniel H Mathalon, Spero C Nicholas, Carla Agurto, Eduardo Castro, Guillermo Cecchi, Pablo Polosecki, Jenna Reinen, Qingqin S Li, Gahan Pandina, Srinivasan Vairavan, Seth Hopkins, Sharin Roth, Michael S Sand, Terri Brister, Ken Duckworth, Carlos A Larrauri, Christoph von der Goltz, Glen Wunderlich, Sara J. Shnider, Brandon Staglin, Sophia Frangou, Arundati Nagendra, Lynsey Bilsland, Loni Ajagbe, Sri Ramulu Pullagura, Martin Sabandal, Alessio Travaglia, Patricia Arean, Shelli Avenevoli, Linda Brady, Gregory Farber, Suzanne Garcia, Robert Heinssen, Sarah Lisanby, Sarah Morris, Laura Rowland, Ming Zhan, Tiffany Farchione, Bernard Fischer, Valentina Mantua, Nicholas Breitborde · 发表于：Schizophrenia Bulletin Open · 年份：2026 · DOI：10.1093/schizbullopen/sgag024 · 研究领域：Sleep and related disorders、Suicide and Self-Harm Studies、Sleep and Wakefulness Research

Background and Hypothesis: Sleep disturbance is a well-established risk factor for suicide, though few studies to date have examined whether sleep disturbance contributes to suicide risk among individuals at clinical high risk for psychosis (CHR). The current study addressed this gap in the literature. We hypothesized that sleep disturbance would have a unique relationship with suicidal ideation/attempts when accounting for other variables in the model. We also hypothesized that the interaction between sleep disturbance/attenuated positive symptoms and sleep disturbance/stress would be related to suicidal ideation/attempts in CHR. Study Design: The current study used data generated by the Accelerating Medicines Partnership® Schizophrenia Observational Study. The total sample included 1,048 participants (827 CHR and 221 community controls). Participants completed measures of suicidal ideation/attempts, attenuated positive symptoms, depressive symptoms, perceived stress, and sleep disturbance. Study Results: Results supported a relationship between sleep disturbance and suicidal ideation/attempts in CHR, with participants who had lifetime ideation and attempts experiencing more sleep disturbance than those with no ideation or attempts. We also found small, but significant positive correlations between sleep disturbance and suicide risk in CHR. When accounting for other variables in the model, the effect of sleep disturbance remained significant for past month ideation, but not ...