Brain structural-functional connectivity coupling and glucose metabolism in adolescents with bipolar disorder and major depressive disorder

作者：Simin Liu, 鍾英彥, Lu Liu, Jing Zhao, Fan Hu, Yanlei Huo, Xin Luo, Chao Ma, Enzhao Cong · 发表于：European Journal of Nuclear Medicine and Molecular Imaging · 年份：2026 · DOI：10.1007/s00259-026-08023-w · 研究领域：Mental Health Research Topics、Bipolar Disorder and Treatment、Functional Brain Connectivity Studies

AIM: F]FDG PET/MRI imaging that may help characterize differences between adolescent with bipolar disorder (BD) and those with major depressive disorder (MDD). MATERIALS AND METHODS: Patients were grouped based on the Hamilton Depression Scale (HAMD) and Hypomania Check List (HCL), and the severity of suicidal ideation and behavior was assessed. 14 BD and 14 MDD adolescent patients were enrolled. Simultaneous PET and MRI data (including 3D T1-weighted imaging, Diffusion Tensor Imaging (DTI), and resting-state functional MRI (fMRI)) were acquired. Functional connectivity (FC) and structural connectivity (SC) were derived from fMRI and DTI respectively. A multiple linear regression model was employed to predict FC from SC. SC-FC coupling was defined as Pearson correlation coefficient between predicted FC and original FC. Using cerebellar gray matter uptake as reference region, standardized uptake value ratio (SUVr) of each brain region was calculated as metabolic parameter. RESULTS: Compared with the MDD group, the BD group showed significantly decreased SC-FC coupling and glucose metabolism in the thalamus. In the BD group, SC-FC coupling in the paracentral lobule showed a significant positive correlation with metabolism (r = 0.70). In the MDD group, SC-FC coupling in cingulate gyrus showed a significant negative correlation with metabolism (r=-0.73). In the BD group, SC-FC coupling in superior parietal lobule, postcentral gyrus, and precentral gyrus correlated significantly w...