Absolute configurations and anti-bacterial activity of two century-old maleidrides

作者：Rongfang Qu, Chenyu Wu, W. Mu, YuXia Lou, Weibing Jiang, Minfeng Jin, Lin‐Fu Liang, Fan Yang · 发表于：Natural Product Research · 年份：2026 · DOI：10.1080/14786419.2026.2696942 · 研究领域：Pharmacological Receptor Mechanisms and Effects、Molecular spectroscopy and chirality、Cyclization and Aryne Chemistry

Two century-old maleidrides 1 and 2 were found in the marine-derived fungus Talaromyces trachyspermus. Their structures were established by the analysis of spectroscopic data. Notably, their absolute configurations were unambiguously assigned by X-ray diffraction analysis. Interestingly, compound 1 showed antibacterial activity against Escherichia coli (IC50 = 103.6 mg/mL). This was the first report on the absolute configuration of compound 2, which has not been determined for near a century.