Targeting Inflammation in Obesity and the Cardiovascular-Kidney-Metabolic Syndrome Spectrum: A Narrative Review

作者：Afsaneh Noormandi, Heiko Bugger, Faisal Aziz, Zvonko Miličević, Dirk von Lewinski, BERNHARD LUDVIK, Verena Parzer, Andreas Zirlik, Thomas R. Pieber, Hans Peter Dimai, Harald Sourij · 发表于：Obesity Facts · 年份：2026 · DOI：10.1159/000553324 · 被引用次数：2 · 研究领域：Chronic Kidney Disease and Diabetes、Adipokines, Inflammation, and Metabolic Diseases、Cardiovascular Disease and Adiposity

BACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome refers to a multi-systemic condition with established pathophysiological connections between obesity, diabetes mellitus, chronic kidney disease, and cardiovascular disease. Chronic low-grade inflammation has been recognized as a common pathophysiological theme linking metabolic dysfunction to multisystem damage of the heart, kidneys, and vasculature. The aim of this narrative review was to summarize the major pharmacologic strategies that target inflammatory pathways in obesity and across the CKM disease spectrum, including metabolic therapies with indirect anti-inflammatory effects and targeted immunomodulatory agents. SUMMARY: New therapies have markedly changed the obesity and the CKM treatment paradigms, with evidence that currently available metabolic medications confer cardiovascular and renal benefits in addition to glycemic control or weight improvement. Nutrient-stimulated hormone therapies and sodium-glucose cotransporter-2 inhibitors (SGLT2i) work synergistically to positively modulate systemic inflammation while maintaining cardiovascular health and cardiometabolic function throughout therapy. Additionally, emerging clinical data for direct anti-inflammatory treatments, such as interleukin-1β/interleukin-6 inhibition and low-dose colchicine, have established inflammation as a modifiable cardiovascular risk factor. Furthermore, therapies that target the liver, such as resmetirom, fibroblast growth factor-21...