Inotuzumab ozogamicin therapy for measurable residual disease in adult acute lymphoblastic leukemia

作者：Elias Jabbour, Caitlin R. Rausch, Hannah Goulart, Nitin Jain, Farhad Ravandi, Abhishek Maiti, Yesid Alvarado, Jan A. Burger, Musa Yılmaz, I. Khouri, Partow Kebriaei, Jeffrey L. Jorgensen, Sa A. Wang, Xuemei Wang, Ejiroghene Mayor, Rebecca Garris, Nicholas J. Short, Hagop M. Kantarjian · 发表于：Blood Cancer Journal · 年份：2026 · DOI：10.1038/s41408-026-01551-6 · 研究领域：Acute Lymphoblastic Leukemia research、Lymphoma Diagnosis and Treatment、HER2/EGFR in Cancer Research

Inotuzumab ozogamicin, an anti-CD22 antibody-drug conjugate, has demonstrated high response rates and measurable residual disease (MRD)-negativity in acute lymphoblastic leukemia (ALL). This phase 2 single-center study evaluated inotuzumab 0.6 mg/m 2 day 1 and 0.3 mg/m 2 day 8 (cycle 1) followed by 0.3 mg/m 2 days 1 and 8 (cycles 2–6) for adults with B-cell ALL in morphologic remission with detectable MRD (≥1 × 10 −4 by multiparameter flow cytometry, BCR::ABL1 transcripts ≥0.01% by polymerase chain reaction [PCR], or ≥1 × 10 −6 by next-generation sequencing [NGS]). Thirty-seven patients (median age 49 years) were treated, including 17 with Philadelphia-chromosome (Ph)-negative ALL and 20 with Ph-positive ALL. Twenty-eight patients (76%) were in first remission (CR1). Overall, 26 patients (70%) achieved MRD-negativity, including 76% of patients with Ph-negative ALL and 65% of patients with Ph-positive ALL. The NGS MRD-negativity rate was 73%. With a median follow-up of 50 months, the median overall survival (OS) was 61 months, with a median relapse-free survival (RFS) of 40 months. Patients treated in CR1 vs CR2+ had a median OS that was not reached versus 14 months, respectively ( p = 0.056). Three cases (8%) of non-fatal sinusoidal obstructive syndrome (SOS) were observed. Inotuzumab was safe and effective at eradicating MRD.